Reference

Comparative mutagenicity of aliphatic epoxides in Salmonella

Comparative mutagenicity of aliphatic epoxides in Salmonella. Canter, Dorothy A.; Zeiger, Errol; Haworth, Steve; Lawlor, Timothy; Mortelmans, Kristien; Speck, William (Natl. Inst. Environ. Health Sci., Bethesda, MD, USA). Mutat. Res., 172(2), 105-38 (English) 1986. CODEN: MUREAV. ISSN: 0027-5107. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) Thirty-seven aliph. epoxides comprising 6 subclasses (unsubstituted aliph. epoxides, halogenated aliph. epoxides, glycidyl esters, glycidates, glycidyl ethers and diglycidyl ethers) were tested, under code, for mutagenicity in Salmonella strains TA98, TA100, TA1535 and TA1537 and(or) TA97 with and without metabolic activation using a standardized protocol. The 4 halogenated aliph. 930-37-0 and 7390-81-0 which are cas registry numbers are also used here. epoxides and the 4 diglycidyl ethers were all mutagenic. The 2 glycidates were neg. in all strain/activation systems used whereas all 5 glycidyl esters were mutagenic. Three of 8 unsubstituted aliph. epoxides and 11 of 12 glycidyl ethers were mutagenic. Glycidol (I) [556-52-5] also was mutagenic whereas 9,10-epoxyoctadecanoic acid 2-ethylhexyl ester [141-38-8] was not mutagenic. Of the 28 mutagenic compds., all but neodecanoic acid 2,3-epoxypropyl ester [26761-45-5] and 2-ethylhexyl glycidyl ether [2461-15-6] were detected in TA100 without activation. The latter 2 were detected only with activation in TA100 and TA1535. The majority of the other 26 chem. were also mutagenic in TA1535 without activation. Good intra- and interlab. reproducibility was seen in the results of each of the 4 chem. tested in >1 set of expts. The current results confirm and extend the observations of other investigators regarding structural effects on the mutagenicity of members of the aliph. epoxide class of chem. .

Silane-based coating compositions

Silane-based coating compositions. (Suwa Seikosha Co., Ltd., Japan). Jpn. Kokai Tokkyo Koho JP 58125764 A2 26 Jul 1983 Showa, 8 pp. (Japanese). (Japan). CODEN: JKXXAF. CLASS: IC: C09D003-82. ICA: C08J003-20.In this article, certain chemicals are used. Some of their cas registry numbers are 1185-55-3 and 16096-31-4 APPLICATION: JP 82-8676 22 Jan 1982. DOCUMENT TYPE: Patent CA Section: 42 (Coatings, Inks, and Related Products) The title compns. are based on hydrolyzed RmRn1SiR24-m-n (R = epoxy org. group; R1 = H or C1-6 hydrocarbyl; R2 = hydrolyzable group; m = 1-3; n = 0-2; m + n ￡3) 20-80, Rp1SiR24-p (p = 0-3) 0-20, org. compd. contg. 1-3 epoxy groups/mol. 15-80, and curing catalysts (Group IV metal halides, alcoholates, or chelates). The coatings are dyeable and scratch-resistant. Thus, g-(glycidyloxy)propyltrimethoxysilane was hydrolyzed with dil. HCl and combined with 2-ethylhexyl glycidyl ether [2461-15-6] and SnCl2 and then dissolved in Ethyl Cellosolve to give a coating compn. .