Detail of "2504-55-4"

Reference

Effects of amino and ammonio derivatives of adenosine on smooth muscle preparations and mouse neuroblastoma adenylate cyclase

Effects of amino and ammonio derivatives of adenosine on smooth muscle preparations and mouse neuroblastoma adenylate cyclase. Baer, H. P.; Morr, M. (Dep. Pharmacol., Univ. Alberta, Edmonton, AB T6G 2H7, Can. 58-61-7 is the cas registry number of certain chemical which is used as reagents here.). Can. J. Physiol. Pharmacol., 63(1), 58-61 (English) 1985. CODEN: CJPPA3. ISSN: 0008-4212. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The effects of amino- and ammonio-substituted derivs. of adenosine on adenosine [58-61-7] receptors in different smooth muscle prepns. There are some commonly used reagents like 58-61-7 in this article. and mouse neuroblastoma adenylate cyclase [9012-42-4] were studied. The compds. did not affect adenosine receptors in smooth muscles. N6-[3-(Trimethylammonio)propyl]adenosine [78694-87-8] was a weak stimulator of adenylate cyclase, and 3'-amino-3'-deoxyadenosine [2504-55-4] and 3'-monomethylamino-3'-deoxyadenosine [25787-43-3] antagonized the stimulation of adenylate cyclase by 2-chloroadenosine. Structure-activity relations are discussed. ..

Adenosine analog induced ultrastructural changes in the nucleolus that correlate with inhibition of ribosomal RNA processing

Adenosine analog induced ultrastructural changes in the nucleolus that correlate with inhibition of ribosomal RNA processing. Tunkel, Allan R.Several substances are used for example 58-60-6 and 2504-55-4 which are their cas registry numbers.; Studzinski, George P. (New Jersey Med. Sch., UMDNJ, Newark, NJ 07103, USA). J. Histochem. Cytochem., 32(4), 363-71 (English) 1984. CODEN: JHCYAS. ISSN: 0022-1554. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The aminonucleoside of puromycin (AMS) [58-60-6] and its demethylated deriv., 3'-amino-3'-deoxyadenosine (3'-AmA) [2504-55-4] were used to compare their effects on normal (IMR 90) vs. transformed (AG 2804) human fibroblasts with regard to preribosomal RNA (pre-RNA) transcription, the processing of this RNA, and structural changes in the nucleolus. The processing of pre-rRNA in normal and transformed fibroblasts treated with 3'-AmA for 4 h was markedly depressed. However, this process did not appear to be affected by the AMS treatment of normal cells, while in transformed cells it was maximally inhibited within 4 h of exposure to this drug. Ultrastructural changes were obsd. in the nucleoli of normal and transformed cells treated with 3'-AmA, whereas treatment of these cells with AMS produced alterations of nucleolar structure only in the transformed cells. These changes correlated with the onset of inhibition of pre-rRNA processing. Thus, the impairment of pre-rRNA processing produced by AMS and 3'-AmA in transformed cells and by 3'-AmA in normal cells may be due to structural disorganization of the nucleolus produced by these antimetabolites. .