Detail of "25472-44-0"

Reference

Synthesis and xanthine oxidase inhibitory analysis of 1H-pyrrolo[3,2-c]pyridine-4,6(5H,7H)-dione (3,7-dideazaxanthine) and two of its derivatives

Synthesis and xanthine oxidase inhibitory analysis of 1H-pyrrolo[3,2-c]pyridine-4,6(5H,7H)-dione (3,7-dideazaxanthine) and two of its derivatives. Schneller, S. W.; Hosmane, R. S.; MacCartney, L. B.; Hessinger, D. A. (Dep. Chem., Univ. South Florida, Tampa, Fla.Several substances are used for example 65523-03-7 which is its cas registry number., USA). J. Med. Chem.Except for chemicals metioned above, 65523-03-7 is also used., 21(9), 990-3 (English) 1978. CODEN: JMCMAR. ISSN: 0022-2623. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Section cross-reference(s): 7, 28 The dideazaxanthine I (X = NH) [65523-03-7] was prepd. by esterifying the acid II (R = OH, R1 = Et) [25472-61-1], aminating II (R = OMe, R1 = Et) [67411-01-2], and cyclizing II (R = NH2, R1 = Et) [65523-04-8]. I (X = NMe) [67139-78-0] was obtained by treating II (R = OEt, R1 = Et) [25472-44-0] with MeNH2 and cyclizing II (R = NMe, R1 = Et) [67411-04-5]. I (X = O) [67411-05-6] was obtained by dehydrating II (R = OH, R1 = H) [25472-38-2] with Ac2O. I (X = NH and NMe) were weak noncompetitive inhibitors of xanthine oxidase [9002-17-9], but I (X = O) was inactive. ..