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CAS No.: | 25892-95-9 |
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Name: | 1-(4-(benzyloxy)-6-hydroxy-2,3-dimethoxyphenyl)ethanone |
Article Data: | 6 |
Molecular Structure: | |
Formula: | C17H18O5 |
Molecular Weight: | 302.327 |
Synonyms: | 4-benzyloxy-2,3-dimethoxy-6-hydroxyacetophenone;4-Benzyloxy-2-hydroxy-5,6-dimethoxyacetophenon;2-hydroxy-4-benzyloxy-5,6-dimethoxyacetophenone;1-(4-(BENZYLOXY)-6-HYDROXY-2,3-DIMETHOXYPHENYL)ETHANONE;QC-8452;4-Benzyloxy-2-hydroxy-5,6-dimethoxyacetophenone;I01-8809; |
Density: | 1.199±0.06 g/cm3(Predicted) |
Melting Point: | 86–87°C |
Boiling Point: | 470.1±40.0 °C(Predicted) |
PSA: | 64.99000 |
LogP: | 3.19100 |
1-(4-(benzyloxy)-3,6-dihydroxy-2-methoxyphenyl)ethan-1-one
dimethyl sulfate
1-(4-(benzyloxy)-6-hydroxy-2,3-dimethoxyphenyl)ethan-1-one
Conditions | Yield |
---|---|
With potassium carbonate In acetone at 60℃; for 5h; | 85% |
With potassium carbonate In acetone Heating; | 59% |
In acetone for 5h; Reflux; |
2-hydroxy-4,6-dimethoxyacetophenone
1-(4-(benzyloxy)-6-hydroxy-2,3-dimethoxyphenyl)ethan-1-one
Conditions | Yield |
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Multi-step reaction with 4 steps 1: 60 percent / aluminium chloride / chlorobenzene / 1 h / Heating 2: 99 percent / K2CO3 / acetone / Heating 3: 29 percent / NaOH; K2S2O8; pyridine / H2O / 24 h / 20 °C 4: 59 percent / K2CO3 / acetone / Heating View Scheme |
2,4,6-trihydroxyacetophenone
1-(4-(benzyloxy)-6-hydroxy-2,3-dimethoxyphenyl)ethan-1-one
Conditions | Yield |
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Multi-step reaction with 5 steps 1: 92 percent / K2CO3 / acetone / 3 h / 65 °C 2: 60 percent / aluminium chloride / chlorobenzene / 1 h / Heating 3: 99 percent / K2CO3 / acetone / Heating 4: 29 percent / NaOH; K2S2O8; pyridine / H2O / 24 h / 20 °C 5: 59 percent / K2CO3 / acetone / Heating View Scheme |
4,6-dihydroxy-2-methoxyacetophenone
1-(4-(benzyloxy)-6-hydroxy-2,3-dimethoxyphenyl)ethan-1-one
Conditions | Yield |
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Multi-step reaction with 3 steps 1: 99 percent / K2CO3 / acetone / Heating 2: 29 percent / NaOH; K2S2O8; pyridine / H2O / 24 h / 20 °C 3: 59 percent / K2CO3 / acetone / Heating View Scheme |
1-(4-(benzyloxy)-2-hydroxy-6-methoxyphenyl)ethan-1-one
1-(4-(benzyloxy)-6-hydroxy-2,3-dimethoxyphenyl)ethan-1-one
Conditions | Yield |
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Multi-step reaction with 2 steps 1: 29 percent / NaOH; K2S2O8; pyridine / H2O / 24 h / 20 °C 2: 59 percent / K2CO3 / acetone / Heating View Scheme | |
Multi-step reaction with 2 steps 1: pyridine; dipotassium peroxodisulfate; tetraethylammonium hydroxide / water / 24 h / 20 °C 2: acetone / 5 h / Reflux View Scheme | |
Multi-step reaction with 2 steps 1.1: pyridine; tetraethylammonium hydroxide / water / 20 °C 1.2: 24 h / 20 °C 1.3: 1 h / 95 °C 2.1: potassium carbonate / acetone / 5 h / 60 °C View Scheme |
1-(4-(benzyloxy)-3,6-dihydroxy-2-methoxyphenyl)ethan-1-one
1-(4-(benzyloxy)-6-hydroxy-2,3-dimethoxyphenyl)ethan-1-one
Conditions | Yield |
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In acetone |
benzyl bromide
1-(4-(benzyloxy)-6-hydroxy-2,3-dimethoxyphenyl)ethan-1-one
Conditions | Yield |
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Multi-step reaction with 5 steps 1: potassium carbonate / acetone / 60 °C 3: potassium hydroxide; pyridine / diethylene glycol; water / 100 °C 4: pyridine; dipotassium peroxodisulfate; tetraethylammonium hydroxide / water / 24 h / 20 °C 5: acetone / 5 h / Reflux View Scheme | |
Multi-step reaction with 5 steps 1.1: potassium carbonate / acetone / 5 h / 0 - 60 °C 2.1: potassium hydroxide / acetone / 5 h / 60 °C 3.1: sodium hydroxide; pyridine / water; diethylene glycol / 2 h / 100 °C 4.1: pyridine; tetraethylammonium hydroxide / water / 20 °C 4.2: 24 h / 20 °C 4.3: 1 h / 95 °C 5.1: potassium carbonate / acetone / 5 h / 60 °C View Scheme |
5,7-dihydroxy-2-phenyl-chromen-4-one
1-(4-(benzyloxy)-6-hydroxy-2,3-dimethoxyphenyl)ethan-1-one
Conditions | Yield |
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Multi-step reaction with 5 steps 1: potassium carbonate / acetone / 60 °C 3: potassium hydroxide; pyridine / diethylene glycol; water / 100 °C 4: pyridine; dipotassium peroxodisulfate; tetraethylammonium hydroxide / water / 24 h / 20 °C 5: acetone / 5 h / Reflux View Scheme | |
Multi-step reaction with 5 steps 1.1: potassium carbonate / acetone / 5 h / 0 - 60 °C 2.1: potassium hydroxide / acetone / 5 h / 60 °C 3.1: sodium hydroxide; pyridine / water; diethylene glycol / 2 h / 100 °C 4.1: pyridine; tetraethylammonium hydroxide / water / 20 °C 4.2: 24 h / 20 °C 4.3: 1 h / 95 °C 5.1: potassium carbonate / acetone / 5 h / 60 °C View Scheme |
7-(benzyloxy)-5-hydroxy-2-phenyl-4H-chromen-4-one
1-(4-(benzyloxy)-6-hydroxy-2,3-dimethoxyphenyl)ethan-1-one
Conditions | Yield |
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Multi-step reaction with 4 steps 2: potassium hydroxide; pyridine / diethylene glycol; water / 100 °C 3: pyridine; dipotassium peroxodisulfate; tetraethylammonium hydroxide / water / 24 h / 20 °C 4: acetone / 5 h / Reflux View Scheme | |
Multi-step reaction with 4 steps 1.1: potassium hydroxide / acetone / 5 h / 60 °C 2.1: sodium hydroxide; pyridine / water; diethylene glycol / 2 h / 100 °C 3.1: pyridine; tetraethylammonium hydroxide / water / 20 °C 3.2: 24 h / 20 °C 3.3: 1 h / 95 °C 4.1: potassium carbonate / acetone / 5 h / 60 °C View Scheme |
1-(4-(benzyloxy)-2-hydroxy-6-methoxyphenyl)ethanone
1-(4-(benzyloxy)-6-hydroxy-2,3-dimethoxyphenyl)ethan-1-one
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: potassium hydroxide; pyridine / diethylene glycol; water / 100 °C 2: pyridine; dipotassium peroxodisulfate; tetraethylammonium hydroxide / water / 24 h / 20 °C 3: acetone / 5 h / Reflux View Scheme | |
Multi-step reaction with 3 steps 1.1: sodium hydroxide; pyridine / water; diethylene glycol / 2 h / 100 °C 2.1: pyridine; tetraethylammonium hydroxide / water / 20 °C 2.2: 24 h / 20 °C 2.3: 1 h / 95 °C 3.1: potassium carbonate / acetone / 5 h / 60 °C View Scheme |