Detail of "26774-88-9"

Reference

Process for the preparation of cephradine

Process for the preparation of cephradine. Lenhardt, Carlos Enrique; Moody, Harold Monro; Van Dooren, Theodorus Johannes Godfried Maria; Heemskerk, Dennis; Hogenboom, Anja Gerarda Margaretha (DSM IP Assets B. V.In this study， 9014-06-6 and 26774-88-9 are also used., Neth.). PCT Int. Appl. WO 2005003367 A2 13 Jan 2005, 24 pp. DESIGNATED STATES: W: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW; RW: AT, BE, BF, BJ, CF, CG, CH, CI, CM, CY, DE, DK, ES, FI, FR, GA, GB, GR, IE, IT, LU, MC, ML, MR, NE, NL, PT, SE, SN, TD, TG, TR. (English). (World Intellectual Property Organization). CODEN: PIXXD2. CLASS: ICM: C12P035-04. ICS: C07D501-00; C12N009-84; C12N011-04. APPLICATION: WO 2004-EP7291 1 Jul 2004. PRIORITY: EP 2003-77102 3 Jul 2003; EP 2003-104445 28 Nov 2003. DOCUMENT TYPE: Patent CA Section: 16 (Fermentation and Bioindustrial Chemistry) The present invention describes a process for prepg. cephradine (I), said process comprising reacting 7-aminodesacetoxycephalosporanic acid (7-ADCA) with D-dihydrophenylglycine in activated form (DHa) in the presence of an enzyme in a reaction mixt. to form I, resulting in a conversion of 7-ADCA into I of 370%, wherein the concn. D-dihydrophenylglycine (DH) in the reaction mixt. is <2 wt.%, wherein the conversion of 7-ADCA into I equals ~100%. The invention also describes a process for the prepn. of I hydrate characterized in that the process comprises reacting 7-ADCA with DHa in the presence of an enzyme in a reaction mixt. to form I, prepg. an aq. soln. comprising at least part of the I, and crystg. the I from said aq. soln. The invention further describes I hydrate obtainable by a process according to invention. The invention also describes I hydrate with an absorbance at 450 nm of <0.050. .