CAS No.288-14-2,Isoxazole Suppliers

Detail of "288-14-2"

CAS Number:

288-14-2

Name:

Isoxazole

Molecular Structure:

Formula:

C₃H₃NO

Molecular Weight:

69.06

Synonyms:

1,2-Oxazole;1-Oxa-2-azacyclopentadiene;2-Azafuran;NSC 137774;

EINECS:

206-018-7

Density:

1.055 g/cm³

Boiling Point:

95.5 °C at 760 mmHg

Flash Point:

8.9 °C

Appearance:

colorless liquid

Hazard Symbols:

Risk Codes:

Safety:

16-23/33-33-29-7/9 Details

Transport Information:

UN 1993 3/PG 2

Reference

Synthesis of isoxazoles and cyanopyridines bearing benzo(b)thiophene nucleus as potential antitubercular and antimicrobial agents: Kachhadia, V. V.; Patel, M. R.; Joshi, H. S. (Department of Chemistry, Saurashtra University, Rajkot 360 005, India). Journal of Sciences, Islamic Republic of Iran, 15(1), 47-51 (English) 2004 University of Tehran. CODEN: JSIIEN. ISSN: 1016-1104. DOCUMENT TYPE: Journal CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) Section cross-reference(s): 1, 10 Isoxazole derivs., e.g., I, and cyanopyridine derivs., e.g., II, have been prepd. by condensing chalcones with hydroxylamine hydrochloride and malononitrile resp. While chalcone starting compds., e.g., III, were synthesized by the reaction of p-(3'-chloro-2'-benzo(b)thiophenoylamino)-acetophenone with different aldehydes. All the compds. were screened for their antitubercular and antimicrobial activities. The structures of newly synthesized compds. were established on the basis of elemental analyses, IR, 1H NMR and Mass spectral data.

Isoxazole derivatives and their use: Isoxazole derivatives and their use. Lempert, Karoly; Doleschall, Gabor; Fetter, Jozsef; Hornyak, Gyula; Nyitrai, Jozsef; Simig, Gyula; Zauer, Karoly (Richter, Gedeon, Vegyeszeti Gyar Rt. ; Biogal Gyogyszergyar, Hung.). Ger. Offen.Chemical with cas number 93276-88-1 also plays role. DE 3405422 A1 30 Aug 1984, 26 pp. (German). (Germany). CODEN: GWXXBX. CLASS: IC: C07D261-02. APPLICATION: DE 84-3405422 15 Feb 1984. PRIORITY: HU 83-661 28 Feb 1983. DOCUMENT TYPE: Patent CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) Section cross-reference(s): 26 The title compds. (I; R, R1 = cyano, COR2; RR1 = CO2CO; R2 = OH, alkoxy, NR3R4; R3, R4 = H, Ph, PhCH2; NR3R4 = heterocyclyl) were prepd. Thus, MeCOC(:CHOEt)CO2Et was cyclocondensed with HONH2.HCl (II) to give Et 5-methyl-4-isoxazolecarboxylate. This was successively sapond., converted to its acid chloride, condensed with CH2(CO2Et)2, and cyclocondensed with II to give biisoxazole III. This was decarboxylated, and cleaved and rearranged by heating in aq. NaOH to give I (R = CO2H, R1 = cyano). I are intermediates for prepn. of the antibiotic thienamycin. .

Detail of "288-14-2"

Isoxazole

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Reference