Detail of "28981-97-7"

CAS Number:
28981-97-7
Name:
4H-[1,2,4]Triazolo[4,3-a][1,4]benzodiazepine,8-chloro-1-methyl-6-phenyl-
Superlist Name:
Alprazolam
Molecular Structure:
Formula:
C₁₇H₁₃ClN₄
Molecular Weight:
308.79
Synonyms:
4H-s-Triazolo[4,3-a][1,4]benzodiazepine,8-chloro-1-methyl-6-phenyl- (8CI);Alcelam;Alplax;Alpram;Alprax;Altraxic;Alzam;Anpress;Ansiopax;Azor;Constan;Frontal;Panix;Prinox;Relaxol;Solanax;TUS 1;Tafil D;Trankimazin;Tricalma;Valeans;Xanax TS;Xanor;Zolarem;Zopax;
EINECS:
249-349-2
Density:
1.369 g/cm³
Melting Point:
228-228.5 °C
Boiling Point:
508.959 °C at 760 mmHg
Flash Point:
261.609 °C
Solubility:
insoluble in water
Appearance:
white crystalline solid
Hazard Symbols:
Xn,T,F
Risk Codes:
22-39/23/24/25-23/24/25-11
Safety:
36-45-36/37-16 Details

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Effects of alprazolam on the activity of rat cerebellar Purkinje neurons: evidence for mediation by norepinephrine: Effects of alprazolam on the activity of rat cerebellar Purkinje neurons: evidence for mediation by norepinephrine. Sorensen, Stephen; Freedman, Robert (Health Sci. Cent., Univ. Colorado, Denver, CO 80262, USA). Drug Dev. Res., 3(6), 555-60 (English) 1983. CODEN: DDREDK. ISSN: 0272-4391. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Acute administration of alprazolam [28981-97-7] caused a dose-dependent slowing of the spontaneous discharge of rat cerebellar Purkinje neurons. This effect was reversed by treatment with propranolol. There was also significantly less slowing in animals in which cerebellar neuronal circuitry was destroyed by pretreatment with 6-hydroxydopamine. Some of the depressant effects of alprazolam may be mediated by an interaction with norepinephrine [51-41-2].

Quinazolines and 1,4-benzodiazepines: Quinazolines and 1,4-benzodiazepines. 81. s-Triazolo[4,3-a][1,4]benzodiazepines by oxidative cyclization of hydrazones. Walser, Armin; Zenchoff, Gladys (Chem. Res. Dep., Hoffmann-La Roche Inc.Several substances like 18091-89-9 may be metioned in this study., Nutley, N. J., USA). J. Med. Chem., 20(12), 1694-7 (English) 1977. CODEN: JMCMAR. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Section cross-reference(s): 28 Twelve 1-substituted s-triazolo[4,3-a][1,4]benzodiazepines were prepd. from hydrazones of 2-hydrazinobenzodiazepines by oxidative cyclization using di-Et azodicarboxylate [75-07-0] or activated MnO2 as oxidizing agents and tested orally in mice in the inclined screen, footshock antifighting, and antipentylenetetrazole tests. Several compds. were active, with 8-chloro-1-methyl-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine (I) [28981-97-7] being most potent. Structure-activity relations are discussed. .