Reference

1,4-Dioxan-2-ones

1,4-Dioxan-2-ones. Suzuki, Shigeto (Chevron Research Co., USA). U.S. US 4070375 24 Jan 1978, 4 pp. (English). (United States of America). CODEN: USXXAM. CLASS: IC: C07D319-10. NCL: 260340600. APPLICATION: US 76-711933 5 Aug 1976. DOCUMENT TYPE: Patent CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) Section cross-reference(s): 23 1,4-Dioxan-2-one (I) and 5-substituted 1,4-dioxanes were prepd. by contacting CO with HCHO and a 1,2-glycol in the presence of HF. Thus, an autoclave contg. 0.30 mol. HOCH2CH2OH and 0.30 mol. HCHO (as tioxane) was pressured to 1980 psig with CO at 24° for 55 min to give a mixt. of 10% unconverted HOCH2CH2OH, 10% glycolic acid and 80% I. I was treated with NaOH in the presence of Raney Ni to give 75 mol.% diglycolic acid and >98% conversion of I.

Synthetic absorbable surgical devices of poly(dioxanone)

Synthetic absorbable surgical devices of poly(dioxanone). Doddi, Namassivaya; Versfelt, Charles C.; Wasserman, David (Ethicon, Inc., USA). 3041-16-5 which is the cas registry number is also used here. U.S. US 4052988 11 Oct 1977, 9 pp. (English).There are some reagents like 3041-16-5 is used in this study. (United States of America). CODEN: USXXAM. CLASS: IC: A61L017-00. NCL: 128335500. APPLICATION: US 76-648236 12 Jan 1976. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) Synthetic absorbable sutures having a high degree of softness and flexibility comprise polymers [COCHR1O[CR2]nCHRO]x (I; R and R1 = H, Me, or Et; n = 1 or 2 provided that when n = 2 at least 2 R = H; x = degree of polymn.). The sutures can be sterilized with 60Co radiation without serious loss of suture strength. Thus, purified p-dioxanone (II) [3041-16-5] was polymd. in presence of a catalyst Et2Zn, and the polymer obtained was dried and melt extruded to obtain monofilament fibers. These sutures when implanted in rat gluteal muscles were absorbed in ~180 days. ..