Detail of "3099-31-8"

Reference

Comparative mutagenicity of halogenated pyridines in the Salmonella typhimurium/mammalian microsome test

Comparative mutagenicity of halogenated pyridines in the Salmonella typhimurium/mammalian microsome test. Claxton, L. D.; Dearfield, K. L.; Spanggord, R. J.; Riccio, E. S.; Mortelmans, K. (Health Eff. Res. Lab., U. S. Environ. Prot. 109-09-1 and 2402-77-9 which are cas registry numbers are also used here. Agency, Research Triangle Park, NC 27711, USA). Mutat. Res., 176(2), 185-98 (English) 1987. CODEN: MUREAV. ISSN: 0027-5107. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) The Salmonella/microsome assay with strains TA97, TA98, TA100 and TA102 was used to examine the potential mutagenicity and structure-activity of 16 halogenated pyridines (I, R = halo, halomethyl; n = 1-2). The chem. reactivity of I suggests that nucleophilic displacement of halogens can occur with halogens at positions 2, 4, and 6 being displaced in addn.-elimination reactions. 2-Chloropyridine [109-09-1] gave a pos. result with rat liver metabolic activation, and 2-fluoropyridine [372-48-5] gave equivocal results under these conditions. Mutagenic responses were also obtained with 2-chloromethylpyridine [4377-33-7] and 3-chloromethylpyridine [3099-31-8], in the presence and absence of rat liver S9. Apparently, I, esp. with halogens at the 2-position, and singly on a Me substituent, have mutagenic activity in the Salmonella assay. .

Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay to coded chemicals

Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay to coded chemicals. I: Results for nine compounds. McGregor, Douglas B.; Martin, Roger; Cattanach, Pamela; Edwards, Ian; McBride, Douglas; Caspary, William J. (Inveresk Res. Inst. Ltd., Musselburgh EH21 7UB, UK).Some commonly used reagents like 106-88-7 and 61-82-5 are used in this experiment. Environ. Mutagen., 9(2), 143-60 (English) 1987. CODEN: ENMUDM. ISSN: 0192-2521. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) Nine substances were tested for their mutagenic potential in the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay, by procedures based upon those described by D. Clive et al. (1979). Cultures were exposed to the chems. for 4 h, then cultured for 2 days before plating in soft agar with or without trifluorothymidine (TFT), 3 mg/mL. Significant responses were obtained with Ca chromate, 3-(chloromethyl)pyridine [3099-31-8], 1,2-epoxybutane [106-88-7], monochloroacetic acid [79-11-8], dicyclohexylthiourea [1212-29-9], 2,4-diaminophenol hydrochloride [137-09-7], and pentachloroanisole [1825-21-4]. Apart from I, rat liver S9 mix was not a requirement for the clearly mutagenic activity of any of the compds. Compds. not identified as mutagens were 3-amino-1,2,4-triazole [61-82-5] and sucrose [57-50-1]. .