Detail of "3326-71-4"

Reference

Preparation of [1,2,4]triazolo[1,5-c]pyrimidines as adenosine A2A receptor antagonists

Preparation of [1,2,4]triazolo[1,5-c]pyrimidines as adenosine A2A receptor antagonists. Atsumi, Toshiyuki; Tsumiki, Hiroshi; Ikeda, Shunichi; Suzuki, Koji ( Kyowa Hakko Kogyo Co., Ltd., Japan). Jpn. Kokai Tokkyo Koho JP 2002037787 A2 6 Feb 2002, 21 pp. (Japanese). (Japan). CODEN: JKXXAF. CLASS: ICM: C07D487-04. APPLICATION: JP 2001-144465 15 May 2001. PRIORITY: JP 2000-142882 16 May 2000. DOCUMENT TYPE: Patent CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) Section cross-reference(s): 1 Title compds. I (X = halo, OQ, lower alkylthio, arylthio, etc.; Q = H, lower alkyl, aryl, arom. heterocyclyl, etc.; Y = halo, OQ, lower alkylthio, arylthio, alkylsulfinyl, arylsulfinyl, etc.; Z = (un)substituted aryl, arom. heterocyclyl), useful for treatment of Parkinson's disease, dementia, and depression, are prepd. by reaction of pyrimidines II (X, Y = same as I; W = halo, OQ2, lower alkylthio, arylthio, alkylsulfinyl, etc.; Q2 = lower alkyl, aryl, arom. heterocyclyl, etc.) with H2NNHCOZ (Z = same as I), cyclization, and rearrangement of III (X, Y, Z = same as above). 2-Amino-4,6-dichloropyrimidine was condensed with 2-furanylcarbonylhydrazide in the presence of KOBu-tert in DMSO at 30° for 2 h to give 97% 2-amino-6-chloro-4[2-(2-furoylhydrazino)]pyrimidine, which was cyclized in the presence of (F3CSO2)O in F3CCO2H under reflux for 8 h and treated with 1-methyl-2-pyrrolidone at 80° for 1 h to give 5-amino-7-chloro-2-(furan-2-yl)[1,2,4]triazolo[1,5-c]pyrimidine. Keywords triazolopyrimidine prepn adenosine receptor antagonist Parkinsons disease treatment triazolopyrimidine prepn dementia treatment triazolopyrimidine prepn depression treatment triazolopyrimidine prepn pyrimidine condensation hydrazide hydrazinopyrimidine cyclization rearrangement Index Entries Purinoceptor antagonists A2; prepn. of triazolopyrimidines as adenosine A2A receptor antagonists Mental disorder dementia, treatment of; prepn. of triazolopyrimidines as adenosine A2A receptor antagonists Antidepressants Antiparkinsonian agents prepn. of triazolopyrimidines as adenosine A2A receptor antagonists 394652-90-5 213896-64-1 56-05-3 3326-71-4 3764-01-0 394652-85-8 394652-86-9 394652-87-0 394652-88-1 394652-89-2 prepn. of triazolopyrimidines as adenosine A2A receptor antagonists

Reaction of carbonylhydrazines and organic peroxides to foam unsaturated polyester resins

Reaction of carbonylhydrazines and organic peroxides to foam unsaturated polyester resins. Kamens, Ernest Rudolph (Pennwalt Corp. , USA). Eur. Pat. Appl. EP 123066 A1 31 Oct 1984, 29 pp. DESIGNATED STATES: R: AT, BE, CH, DE, FR, GB, IT, LI, NL, SE. (English). (European Patent Organization). CODEN: EPXXDW. CLASS: IC: C08J009-06. APPLICATION: EP 84-102170 1 Mar 1984. PRIORITY: US 83-479300 28 Mar 1983. DOCUMENT TYPE: Patent CA Section: 37 (Plastics Manufacture and Processing) Low-d. foams are prepd. from a compn. comprising polymerizable and/or crosslinkable monomer and/or polymer, a carbonylhydrazine blowing agent, a peroxide curing agent, and a Cu or Fe salt promoter. Thus, an unsatd. polyester, Laminac PDL 989 [87397-38-4] contg. ~35% styrene, 50% 2-furoic acid hydrazide [3326-71-4] in DMF (1.35 g/100 g resin), 45% FeCl3 (0.5 g/100 g resin), and 3.0 phr Me Et ketone peroxide [1338-23-4] were mixed to give a foam having d. 37 lb/ft3.