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Basic Information
| CAS No.: | 3398-22-9 |
|---|---|
| Name: | trans-4-Hydroxy-D-proline |
| Article Data: | 9 |
| Molecular Structure: | |
|
|
|
| Formula: | C5H9NO3 |
| Molecular Weight: | 131.131 |
| Synonyms: | D-Proline,4-hydroxy-, trans-;(2R,4S)-(+)-4-Hydroxy-D-proline;4-(S)-Hydroxypyrrolidine-2-(R)-carboxylic acid;D-Hydroxyproline;D-trans-4-Hydroxyproline;NSC 206273;trans-4-Hydroxy-D-proline; |
| EINECS: | 219-963-5 |
| Density: | 1.395 g/cm3 |
| Melting Point: | 260°C |
| Boiling Point: | 355.2 °C at 760 mmHg |
| Flash Point: | 168.6 °C |
| Appearance: | White crystal or crystalline powder |
| Hazard Symbols: |
 Xn
|
| Risk Codes: | 22-36/37/38-43 |
| Safety: | 24/25-36/37-26 |
| PSA: | 69.56000 |
| LogP: | -0.87740 |
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Synthetic route
- 3398-22-9
trans-4-hydroxyproline
Conditions
| Conditions | Yield |
|---|---|
| With ammonia; sodium at -70℃; for 3.5h; Inert atmosphere; | 79% |
- 77449-96-8
N-Acetyl-allo-4-(p-toluenesulfonyloxy)-D-proline
- 3398-22-9
trans-4-hydroxyproline
Conditions
| Conditions | Yield |
|---|---|
| With sodium hydroxide Erhitzen des Reaktionsprodukts mit wss. HCl; |
- 114673-33-5
trans-1-(3,5-dinitro-benzoyl)-4-hydroxy-D-proline
- 3398-22-9
trans-4-hydroxyproline
Conditions
| Conditions | Yield |
|---|---|
| With hydrogenchloride | |
| With hydrogenchloride |
- 3398-22-9
trans-4-hydroxyproline
Conditions
| Conditions | Yield |
|---|---|
| With ammonia at 95 - 100℃; |
- 77449-96-8
N-Acetyl-allo-4-(p-toluenesulfonyloxy)-D-proline
- 3398-22-9
trans-4-hydroxyproline
Conditions
| Conditions | Yield |
|---|---|
| anschliessend Erhitzen mit wss. HCl; |
Conditions
| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 1: aqueous NaOH 2: (1S,2S)-2-amino-1-<4-nitro-phenyl>-propane-1,3-diol 3: aqueous HCl View Scheme | |
| Multi-step reaction with 3 steps 1: sodium hydroxide 2: (1S,2S)-2-amino-1-(4-nitrophenyl)propane-1,3-diol 3: hydrogenchloride View Scheme |
- 77449-95-7
N-Acetyl-allo-4-(p-toluenesulfonyloxy)-D-proline Methyl Ester
- 3398-22-9
trans-4-hydroxyproline
Conditions
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: aqueous methanol. NaOH 2: aqueous NaOH / Erhitzen des Reaktionsprodukts mit wss. HCl View Scheme |
- 103078-90-6, 114673-32-4, 114673-33-5
trans-1-(3,5-dinitro-benzoyl)-4-hydroxy-DL-proline
- 3398-22-9
trans-4-hydroxyproline
Conditions
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: brucine 2: aqueous HCl View Scheme | |
| Multi-step reaction with 2 steps 1: (1S,2S)-2-amino-1-<4-nitro-phenyl>-propane-1,3-diol 2: aqueous HCl View Scheme | |
| Multi-step reaction with 2 steps 1: (1S,2S)-2-amino-1-(4-nitrophenyl)propane-1,3-diol 2: hydrogenchloride View Scheme |
Conditions
| Conditions | Yield |
|---|---|
| With shaking calcined L-Pro chiral ordered mesoporous silica Resolution of racemate; |
- 3398-22-9
trans-4-hydroxyproline
Conditions
| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 1: triethylsilane; boron trifluoride diethyl etherate / dichloromethane / 3 h / 0 - 30 °C / Inert atmosphere 2: Jones reagent / acetone / 4 h / 0 °C / Inert atmosphere 3: ammonia; sodium / 3.5 h / -70 °C / Inert atmosphere View Scheme |
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trans-4-Hydroxy-D-proline
Chemistry
Molecular Formula:C5H9NO3
Molar mass:131.12986g/mol
Structure of trans-4-Hydroxy-D-proline(3398-22-9):
Synonyms of trans-4-Hydroxy-D-proline(3398-22-9):L-Hydroxyproline;H-D-PRO(4-HYDROXY)-OH;H-D-PRO(TRANS-4-HYDROXY)-OH;H-D-HYP-OH;Proline, 4-hydroxy-;TRANS-D-HYDROXYPROLINE;4-Hydroxiproline(2R,4S)-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID;
Density:1.395 g/cm3
Flash Point:168.6 °C
Boiling Point:355.2 °C at 760 mmHg
Index of Refraction:1.54
Vapour Pressure:1.8E-06 mmHg at 25°C
Melting point:260°C
Molar mass:131.12986g/mol
Structure of trans-4-Hydroxy-D-proline(3398-22-9):
Synonyms of trans-4-Hydroxy-D-proline(3398-22-9):L-Hydroxyproline;H-D-PRO(4-HYDROXY)-OH;H-D-PRO(TRANS-4-HYDROXY)-OH;H-D-HYP-OH;Proline, 4-hydroxy-;TRANS-D-HYDROXYPROLINE;4-Hydroxiproline(2R,4S)-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID;
Density:1.395 g/cm3
Flash Point:168.6 °C
Boiling Point:355.2 °C at 760 mmHg
Index of Refraction:1.54
Vapour Pressure:1.8E-06 mmHg at 25°C
Melting point:260°C
Safety Profile
Hazard Codes:Xn
Risk Statements:
22: Harmful if swallowed
36: Irritating to the eyes
37: Irritating to the respiratory system
38: Irritating to the skin
43: May cause sensitization by skin contact
Safety Statements:
24: Avoid contact with skin
25: Avoid contact with eyes
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice36: Wear suitable protective clothing
37: Wear suitable gloves
Risk Statements:
22: Harmful if swallowed
36: Irritating to the eyes
37: Irritating to the respiratory system
38: Irritating to the skin
43: May cause sensitization by skin contact
Safety Statements:
24: Avoid contact with skin
25: Avoid contact with eyes
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice36: Wear suitable protective clothing
37: Wear suitable gloves
Specification
Product Categories of trans-4-Hydroxy-D-proline(3398-22-9):Pyrrolidines;Carboxylic Acids;Carboxylic Acids;Chiral Compound