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Detail of "38194-50-2"

  • MSDS Download
  • CAS Number:
  • 38194-50-2
  • Name:

  • 1H-Indene-3-aceticacid, 5-fluoro-2-methyl-1-[[4-(methylsulfinyl)phenyl]methylene]-, (1Z)-

  • Superlist Name:
  • Sulindac
  • Molecular Structure:
  • Formula:
  • C20H17FO3S
  • Molecular Weight:
  • 356.42
  • Deleted CAS:
  • 49627-22-7
  • Synonyms:
  • 1H-Indene-3-aceticacid, 5-fluoro-2-methyl-1-[[4-(methylsulfinyl)phenyl]methylene]-, (Z)-;(Z)-5-Fluoro-2-methyl-1-[p-(methylsulfinyl)benzylidene]indene-3-acetic acid;Aflodac;Arthrocine;Artribid;Clinoril;Clisundac;Imbaral;MK 231;Mobilin;Reumofil;Reumyl;Sudac;
  • EINECS:
  • 253-819-2
  • Density:
  • 1.38 g/cm3
  • Melting Point:
  • 182-185 °C
  • Boiling Point:
  • 581.6 °C at 760 mmHg
  • Flash Point:
  • 305.6 °C
  • Appearance:
  • yellow crystalline solid
  • Hazard Symbols:
  • HarmfulXn
  • Risk Codes:
  • 22-63-42/43
  • Transport Information:
  • UN 3249
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CAS No.38194-50-2 Sulindac

Assay:99%  Appearance:powder  Package:25kg/drum

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CAS No.38194-50-2 Sulindac

Category : Agrochemicals CAS NO : 38194-50-2 EC NO : 253-819-2 MF : C20H17FO3S MW : 356.4106 Synonyms : Sulindac [USAN:INN:BAN:JAN];Sulindac;(Z)-5-Fluoro-2-methyl-1-((p-(methylsulfinyl)phenyl)methylene)-1H-indene-3-acetic acid;1H-Indene-3-acetic acid, 5-fluoro-2-methyl-1

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Assay:99%  Appearance:Yellow cryst...

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Sulindac,Cas#38194-50-2

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CAS No.38194-50-2 Sulindac

1H-Indene-3-aceticacid, 5-fluoro-2-methyl-1-[[4-(methylsulfinyl)phenyl]methylene]-, (1Z)-

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CAS No.38194-50-2 Sulindac

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Sulindac, USP

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Sulindac

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CAS No.38194-50-2 Sulindac

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Sulindac(Clinoril) is a non-steroidal anti-inflammatory drug of the arylalkanoic acid class.

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Reference

Antiinflammmatory drugs: protection of a bacterial virus as an in vitro biological measure of free radical activity
Antiinflammmatory drugs: protection of a bacterial virus as an in vitro biological measure of free radical activity. Hiller, K. O.; Hodd, P. L.; Willson, R. L. (Biochem. Dep., Brunel Univ., Uxbridge UB8 3PH, UK). Chem.-Biol. Interact., 47(3), 293-305 (English) 1983. CODEN: CBINA8. ISSN: 0009-2797. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The effects of the hydroxyl free radical, the superoxide free radical, and the trichloromethyl peroxy free radical on the survival of bacteriophage T2 were studied in the absence and presence of several nonsteroidal anti-inflammatory drugs (NSAID). The trichloromethylperoxy radical-derived from CCl4 is considerably more effective than the hydroxyl radical in inactivating the virus; the superoxide radical has only a minor inactivating effect. All of the NSAID investigated (flurbiprofen [5104-49-4], ibuprofen [15687-27-1], sulindac [38194-50-2], piroxicam [36322-90-4], benoxaprofen [51234-28-7], mefenamic acid [61-68-7], diflunisal [22494-42-4], aspirin [50-78-2], D-penicillamine [52-67-5], indomethacin [53-86-1], and metiazinic acid [13993-65-2]) inhibit inactivation by the hydroxyl free radical. This is an agreement with the high rate consts. of reaction with this radical detd. using the fast-reaction technique of pulse radiolysis, i.e. (k >109M-1s-1). 11062-77-4 and 13993-65-2 which are cas registry numbers of chemicals are mentioned. The S-contg. drugs, metiazinic acid, piroxicam, penicillamine, and sulindac, as well as the indole deriv. indomethacin, protect the virus from inactivation by the trichloromethyl peroxy radical (the dose modifying factor, DMF >20). In contrast, acetylsalicylic acid-related drugs, such as diflunisal, the anthranilic acid deriv., mefenamic acid, and some phenylpropionic acid derivs., such as flurbiprofen, exhibit only a very small or no protective effect (DMF <2). As with hydroxyl radical, the ability of the drugs to protect the virus from inactivation by the peroxy radical is in agreement with their corresponding rate consts. of reaction detd. by pulse radiolysis. .
Synergistic compositions of nalbuphine and non-narcotic analgesic compounds
Synergistic compositions of nalbuphine and non-narcotic analgesic compounds. Schmidt, William Koch (du Pont de Nemours, E. I., and Co. , USA). Eur. Pat. Appl. EP 97953 A2 11 Jan 1984, 47 pp. DESIGNATED STATES: R: AT, BE, CH, DE, FR, GB, IT, LI, LU, NL, SE. (English). (European Patent Organization). CODEN: EPXXDW. CLASS: IC: A61K031-485. ICI: A61K031-485, A61K031-19; A61K031-485, A61K031-40; A61K031-485, A61K031-405; A61K031-485, A61K031-415.Several substances with their cas registry numbers 33369-31-2 and 20594-83-6 may be metioned in this study. APPLICATION: EP 83-106282 28 Jun 1983. PRIORITY: US 82-393807 30 Jun 1982; US 82-393808 30 Jun 1982; US 82-393805 30 Jun 1982; US 82-393803 30 Jun 1982; US 82-393804 30 Jun 1982; US 82-393809 30 Jun 1982. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 1 Combinations of nalbuphine (I) [20594-83-6] and certain non-narcotic analgesics provide synergistic analgesic activity. Tablets were prepd. contg. I-HCl [23277-43-2] 30.0 and ibuprofen [15687-27-1] 60.0 mg/tablet. The synergistic activity of I-HCl with ibuprofen, zomepirac Na [64092-48-4], indomethacin [53-86-1], tiflamizole [62894-89-7], sulindac [38194-50-2], or flurbiprofen [5104-49-4] was demonstrated in oral combinations in the mouse antiphenylquinone writhing test. .
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