Detail of "3964-81-6"

Reference

High-performance liquid chromatographic assay for azatadine in human urine

High-performance liquid chromatographic assay for azatadine in human urine. Alton, Kevin B.; Petruzzi, Ralph F.; Patrick, James E. (Dep. Drug Metab. Pharmacokinet., Schering Corp., Bloomfield, NJ 07003, USA). J. Chromatogr., 385, 249-59 (English) 1987. CODEN: JOCRAM. ISSN: 0021-9673. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) A HPLC assay for the quant. detn. of azatadine [3964-81-6] and a base (1M NaOH) hydrolyzable conjugate of azatadine in human urine has been developed. Reversed-phase sepn. of azatadine and the internal std., 8-chloroazatadine, was accomplished on a 300 ′ 3.9 mm I.D. mBondapak CN column. Following liq.-liq. extn. from urine, azatadine was quant. detd. by UV detection at 214 nm. No interferences were obsd. in the exts. obtained from drug-free urine. Detector response (peak area ratio) was linear from 10 to 2500 ng/mL. This method provides accurate and precise detns. of the unchanged and hydrolyzed drug in human urine, following the twice daily oral administration (1-2 mg) of azatadine maleate.

Pharmacology of upper airways challenge

Pharmacology of upper airways challenge. Proud, David; Kagey-Sobotka, Anne; Naclerio, Robert M.; Lichtenstein, Lawrence M. (Sch. Med., Johns Hopkins Univ., Baltimore, MD 21239, USA). Int. Arch.Several reagents with their cas registry numbers 53-03-2 and 58-55-9 are used here. Allergy Appl. Immunol., 82(4), 493-7 (English) 1987. CODEN: IAAAAM. ISSN: 0020-5915. DOCUMENT TYPE: Journal; General Review CA Section: 1 (Pharmacology) Section cross-reference(s): 2 A review with 19 refs. A model of nasal provocation was used to study the effects of pharmacol. interventions upon various types of inflammatory reactions of the upper airways of humans. Pretreatment of allergic individuals with aspirin [50-78-2] reduces the levels of prostaglandins in nasal secretions during the immediate allergic response but has no effect on symptoms. Theophylline [58-55-9] and azatadine [3964-81-6] both reduce symptoms and the levels of mast cell mediators during the allergic response. By contrast, azatadine has no effect on symptoms or mediator levels during the response to challenge with cold, dry air, suggesting different mechanisms of mast cell activation in response to allergen and cold, dry air. Both topical and systemic steroids are effective in reducing symptoms and mediators during the late allergic response, but topical steroids also significantly inhibit the immediate response. .