3964-81-6

Basic information

• Product Name: AzatadineMaleate
• Synonyms: 6,11-Dihydro-11-(1-methyl-4-piperidylidene)-5H-benzo[5,6]cyclohepta[1,2-b]pyridine;6,11-Dihydro-11-(1-methylpiperidin-4-ylidene)-5H-benzo[5,6]cyclohepta[1,2-b]pyridine;6,11-Dihydro-11-(1-Methyl-4-piperidinylidene)-5H-benzo[5,6]cyclohepta[1,2-b]pyridine;5H-Benzo[5,6]cyclohepta[1,2-b]pyridine, 6,11-dihydro-11-(1-Methyl-4-piperidinylidene)-
• CAS NO: 3964-81-6
• Molecular Formula: C₂₀H₂₂N₂
• Molecular Weight: 290.4
• EINECS: 223-615-8
• Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 3964-81-6.mol
• Article Data: 2

Chemical Properties

• Melting Point: 124-126°
• Boiling Point: 450.1 °C at 760 mmHg
• Flash Point: 226 °C
• Appearance: White or off-white crystalline powder
• Density: 1.127
• PKA: 8.74±0.20(Predicted)
• CAS DataBase Reference: AzatadineMaleate(CAS DataBase Reference)
• NIST Chemistry Reference: AzatadineMaleate(3964-81-6)
• EPA Substance Registry System: AzatadineMaleate(3964-81-6)

Safety Data

• Hazardous Substances Data: 3964-81-6(Hazardous Substances Data)

Usage

Uses

Antihistaminic.

Definition

ChEBI: A benzo[5,6]cyclohepta[1,2-b]pyridine having a 1-methylpiperidin-4-ylidene group at the 11-position.

Brand name

Optimine (Schering).

InChI:InChI=1/C20H24N2.2C4H4O4/c1-22-13-10-16(11-14-22)19-18-7-3-2-5-15(18)8-9-17-6-4-12-21-20(17)19;2*5-3(6)1-2-4(7)8/h2-7,12,16,19H,8-11,13-14H2,1H3;2*1-2H,(H,5,6)(H,7,8)/b;2*2-1-

Upstream product

• 38092-89-6 N-methyldesloratadine 
• 63463-36-5 (1-methyl-4-piperidyl)magnesium chloride 
• 32998-95-1 N-tert-butyl-3-methylpyridine-2-carboxamide 
• 3964-73-6 5,6-Dihydro-11H-benzo<5,6>cyclohepta<1,2-b>pyridin-11-one 
• 3964-79-2 11-(1-methyl-piperidin-4-yl)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ol 
• 14578-23-5 3-phenethyl-pyridine-2-carbonitrile 
• 100-44-7 benzyl chloride 

Downstream Products

• 38092-95-4 desmethylazatadine 
• 79779-59-2 11-(1-phenoxycarbonyl-4-piperidylene)-5,6-dihydro-11H-benzo<5,6>cyclohepta<1,2-b>pyridine 

Relevant articles and documents

Preparation method of loratadine impurity

The invention provides a preparation method of a loratadine impurity. The method comprises the following steps: dissolving methylloratadine in a solvent, adding an acid and a catalyst into the solution, heating the solution in a hydrogen atmosphere for a heating reaction, and carrying out cooling, filtering, concentrating and purifying to obtain the loratadine impurity represented by the formula II. According to the technical scheme, the raw materials are cheap and easily available, the operation and post-treatment are simple, the reaction conditions are mild, the process is stable, the yieldis high, and the reproducibility is good. According to the technical scheme, the blank that no loratadine impurity preparation method exists in China is filled up, the cost of developing the medicineby pharmaceutical enterprises can be reduced, and the preparation method has a very good industrial application prospect.