CAS No.40391-99-9,Pamidronic acid Suppliers

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Basic Information

Molecular Structure:
CAS No.:	40391-99-9
Name:	Pamidronic acid
Article Data:	32

Formula:	C₃H₁₁NO₇P₂
Molecular Weight:	279.034
Synonyms:	Phosphonicacid, (3-amino-1-hydroxypropylidene)bis- (9CI);(3-Amino-1-hydroxypropylidene)-1,1-bisphosphonate;(3-Amino-1-hydroxypropylidene)bisphosphonic acid;(a-Hydroxy-g-aminopropylidene)diphosphonic acid;3-Amino-1-hydroxypropane-1,1-diphosphonic acid;3-Amino-1-hydroxypropylidene-1,1-bisphosphonic acid;3-Amino-1-hydroxypropylidenediphosphonic acid;Amidronic acid;Phosphonic acid,P,P'-(3-amino-1-hydroxypropylidene)bis-;Panolin;Propane-1-hydroxy-3-amino-1,1-diphosphonic acid;
EINECS:	254-905-2
Density:	1.998 g/cm³
Melting Point:	226-228 °C
Boiling Point:	658.7 °C at 760 mmHg
Flash Point:	352.2 °C
Appearance:	COA
PSA:	180.93000
LogP:	-0.96300

Synthetic route

: 107-95-9
3-amino propanoic acid

: 40391-99-9
pamidronate

Conditions

Conditions	Yield
With methanesulfonic acid; phosphorous acid; phosphorus trichloride at 65 - 70℃; Inert atmosphere;	99%
Stage #1: 3-amino propanoic acid With phosphorus trichloride In methanesulfonic acid at 80 - 85℃; Stage #2: With water In methanesulfonic acid at 105℃; for 4h;	85%
With phosphonic Acid; phosphorus trichloride In chlorobenzene at 100℃; for 3h; Inert atmosphere;	82%

: 948317-73-5
[3-(benzyloxycarbonylamino)-1-hydroxy-1-phosphonopropyl]phosphonic acid

: 40391-99-9
pamidronate

Conditions

Conditions	Yield
With hydrogen; palladium on activated charcoal In methanol for 24h;	90%

: 917092-03-6
[3-(1,3-dioxo-1,3-dihydroisoindol-2-yl)-1-hydroxy-1-phosphonopropyl]phosphonic acid

: 40391-99-9
pamidronate

Conditions

Conditions	Yield
With hydrazine hydrate In water at 20℃; for 0.5h;	67%
With hydrogenchloride In water for 5.5h; Reflux;

: 40391-99-9
pamidronate

: 3-amino-1-hydroxypropane-1,1-diphosphonic acid disodium salt

Conditions

Conditions	Yield
With sodium methylate In ethanol	99.6%
With sodium methylate In methanol	97.9%
With sodium hydroxide In water

: copper(II) carbonate

: 40391-99-9
pamidronate

: 7732-18-5
water

: 2Cu(2+)*2H3NC2H4C(OH)(PO3)PO3H(2-)*H2O=[Cu2(H3NC2H4C(OH)(PO3)PO3H)2]*H2O

Conditions

Conditions	Yield
In water High Pressure; equimol., heatd at 70°C in a closed flask for for 3 wk; crysts. decanted, dried (air); elem. anal.;	95%

...Expand

: 50-00-0
formaldehyd

: 40391-99-9
pamidronate

: 63132-39-8
olpadronate

Conditions

Conditions	Yield
With formic acid for 17h; Heating;	92%

: 55750-63-5
6-maleimidohexanoic acid N-hydroxylsuccinimide ester

: 40391-99-9
pamidronate

: (3‐{[6‐(2,5‐dioxo‐2,5‐dihydro‐1H‐pyrrol‐1‐yl)hexanoyl]amino}‐1‐hydroxypropane‐1,1‐diyl)bis(phosphonic acid)

Conditions

Conditions	Yield
With sodium hydroxide In water; acetone at 20℃; pH=8 - 9;	88%

: 40391-99-9
pamidronate

: disodium-1,3-dihydroxypropane-1,1-diphosphonate

Conditions

Conditions	Yield
With sodium nitrite In Na2 -salt; water	85%

: 40391-99-9
pamidronate

: 7732-18-5
water

: copper(II) nitrate

: 3Cu(2+)*2C3NH8P2O7(3-)*2H2O=Cu3(C3NH8P2O7)2*2H2O

Conditions

Conditions	Yield
With NaOH In water High Pressure; a mixt. of Cu-contg. compd. (0.5 mmol), ligand (0.5 mmol) and water adjusted to pH 4.2 with NaOH aq. soln. was sealed in a Teflon-lined autoclave and heated at 160°C for 3 d; slow cooling to room temp.; crystals were filtered off and washed with water; elem. anal.;	85%

...Expand

: 5190-68-1
4-chloroquinazoline

: 40391-99-9
pamidronate

: [1-hydroxy-3-(quinazolin-4-ylamino)propane-1,1-diyl]bis(phosphonic acid)

Conditions

Conditions	Yield
Stage #1: 4-chloroquinazoline; pamidronate With potassium carbonate In water at 95℃; for 24h; Reflux; Stage #2: With hydrogenchloride In water at 5℃; for 24h; pH=1;	82%

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Chemistry

IUPAC Name: (3-Amino-1-hydroxy-1-phosphonopropyl)phosphonic acid
Molecular Formula: C₃H₁₁NO₇P₂
Molecular Weight: 235.07 g/mol
Canonical SMILES: C(P(O)(O)=O)(P(O)(O)=O)(CCN)O
InChI: InChI=1/C3H11NO7P2/c4-2-1-3(5,12(6,7)8)13(9,10)11/h5H,1-2,4H2,(H2,6,7,8)(H2,9,10,11)
EINECS: 254-905-2
Classification Code: Bone Density Conservation Agents; Bone resorption inhibitor
Product Categories: (intermediate of pamidronate disodium); Delavirdine
Density: 1.998 g/cm³
Flash Point: 352.2 °C
Enthalpy of Vaporization: 111 kJ/mol
Boiling Point: 658.7 °C at 760 mmHg
Melting Point: 226-228 °C
Vapour Pressure of Pamidronic acid (CAS NO.40391-99-9): 3.79E-20 mmHg at 25 °C

Uses

Pamidronic acid (CAS NO.40391-99-9) is used to prevent bone loss, and treat osteoporosis. It is also used to strengthen bone in Paget's disease, to prevent bone loss due to steroid use, and in certain cancers with high propensity to bone, such as multiple myeloma. It is also used as an experimental treatment of the bone disorder known as Osteogenesis Imperfecta, or brittle bones.

Specification

Pamidronic acid (CAS NO.40391-99-9), its Synonyms are Amidronate ; Acide pamidronique ; Acido pamidronico ; Pamidronate ; (3-Amino-1-hydroxypropylidene)bisphosphonic acid ; (3-Amino-1-hydroxypropylidene)diphosphonic acid .