Detail of "4205-90-7"

Reference

Clonidine promotes the accumulation of calcium-45 in pancreatic b-cell organelles

Clonidine promotes the accumulation of calcium-45 in pancreatic b-cell organelles. Andersson, Tommy; Nygren, Peter (Dep. Med. Cell Biol., Univ. Uppsala, Uppsala S-751 23, Swed.). Res. Commun. Chem. Pathol. Pharmacol.Several substances with their cas registry numbers 50-99-7 and 7440-70-2 may be metioned in this study., 42(3), 369-76 (English) 1983. CODEN: RCOCB8. ISSN: 0034-5164. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 2 Glucose [50-99-7]-stimulated insulin [9004-10-8] release from pancreatic islets of ob/ob-mice was inhibited by 10-9 M of the a2-adrenergic agonist clonidine [4205-90-7]. This inhibitory effect was abolished by 10-7 M of the antagonist yohimbine. Loading the islets with 45Ca during the clonidine exposure followed by isolation of subcellular fractions under conditions known to minimize the 45Ca redistribution resulted in increased accumulation of the isotope in the mitochondrial and microsomal fractions. Apparently, clonidine inhibits glucose-stimulated insulin release by increasing the organelle sequestration of Ca2+. .

Time course of brain MHPG-SO4 [3-methoxy-4-hydroxyphenylethyleneglycol sulfate] level following stimulation of pre- and post-synapitic a-adrenoceptors by clonidine

Time course of brain MHPG-SO4 [3-methoxy-4-hydroxyphenylethyleneglycol sulfate] level following stimulation of pre- and post-synapitic a-adrenoceptors by clonidine. Kohno, Yasuko; Tanaka, Masatoshi; Glavin, Gary B.; Hoaki, Yoshio; Tsuda, Akira; Nagasaki, Nobuyuki (Sch. Med., Kurume Univ., Kurume 830, Japan). Jpn. J. Pharmacol., 34(1), 125-7 (English) 1984. 3415-67-6 and 51-41-2 are cas registry numbers of chemicals which are used as reagents here. CODEN: JJPAAZ. ISSN: 0021-5198. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 2 Ten percent decreases (relative to control values) in 3-methoxy-4-hydroxyphenylethyleneglycol sulfate (MHPG-SO4) [3415-67-6] could be detected in specific regions of rat brain 15 min after clonidine (I) [4205-90-7] at 300 mg/kg and 30 min after 50 and 300 mg/kg I. In all brain regions, MHPG-SO4 was apparently reduced 60-120 min after I injection. The accumulation of noradrenaline (NA) [51-41-2] induced by I was found after 30 min in 2 brain regions and became evident in most brain regions after 120 min. Overall, the decrease in NA release in the brain is reflected earlier and more markedly by its metabolite MHPG-SO4 than by NA. .