Detail of "427-63-4"

CAS Number:
427-63-4
Name:
Spiro[benzofuran-2(3H),1'-[2,5]cyclohexadiene]-2'-carboxylicacid, 5,7-dichloro-4-hydroxy-6'-methoxy-6-methyl-3,4'-dioxo-, methyl ester,(1'R)-
Molecular Structure:
Formula:
C17H12 Cl2 O7
Molecular Weight:
399.179
Synonyms:
Geodin(6CI); (+)-Geodin; Estin; d-Geodin
Density:
1.61 g/cm³
Boiling Point:
652.1 °C at 760 mmHg
Flash Point:
348.2 °C

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Interactions of geodin antibiotics and some other naturally occuring a,b-unsaturated carbonyl compounds with low molecular thiols and thiolproteins: Interactions of geodin antibiotics and some other naturally occuring a,b-unsaturated carbonyl compounds with low molecular thiols and thiolproteins. Sturdik, Ernest; Drobnica, Ludovit; Sladkova, Vlasta; Krchnava, Edita (Dep. Tech. Microbiol. Biochem., Slovak Polytech. Univ., Bratislava 812 37, Czech.). Biologia (Bratislava), 38(12), 1229-41 (English) 1983. CODEN: BLOAAO. ISSN: 0006-3088. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Geodin (I) [427-63-4], trypacidin (II) [1900-29-4], plumbagin (III) [481-42-5], terreic acid [121-40-4] and monorden [12772-57-5] were potent inhibitors of glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.12) [9001-50-7] and other sulfhydryl (SH) enzymes, glucose-6-phosphate dehydrogenase (EC 1.1.1.49) [9001-40-5], glutathione reductase (EC 1.6.4.2) [9001-48-3] and malate dehydrogenase (EC 1.1.1.37) [9001-64-3]. The expts. with reduced glutathione [70-18-8], as the model low mol. thiol, showed that these compds. were reactive thiol-combining agents. The ability to react with SH groups is discussed in the light of the biol. activities of these naturally occurring a,b-unsatd. carbonyl compds. Structure-activity relations are discussed.

Studies on the metabolic products of Aspergillus terreus: Studies on the metabolic products of Aspergillus terreus. III.Several substances are used for example 427-63-4 which is its cas registry number. Metabolites of the strain IFO 8835. (1). Kiriyama, Noriki; Nitta, Keiichi; Sakaguchi, Yoshiaki; Taguchi, Yasuhisa; Yamamoto, Yuzuru (Fac. Pharm. Sci., Kanazawa Univ., Kanazawa, Japan). Chem. Pharm. Bull.Some chemicals with cas registry numbers like 427-63-4 are also used., 25(10), 2593-601 (English) 1977. CODEN: CPBTAL. DOCUMENT TYPE: Journal CA Section: 10 (Microbial Biochemistry) A new type metabolite (I) was isolated from A. terreus var africanus IFO 8835 together with terrein, 3,6-dihydroxytoluquinone, emodin, questin, sulochrin, dihydroerdin, geodin, asterric acid, and aspulvinone D. I was biosynthsized by intact condensation of 2 phenylpropanoids between C-2 and C-3'. ..