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CAS No.: | 4480-83-5 |
---|---|
Name: | Diglycolic anhydride |
Article Data: | 12 |
Molecular Structure: | |
Formula: | C4H4O4 |
Molecular Weight: | 116.073 |
Synonyms: | Aceticacid, oxydi-, cyclic anhydride (8CI);Diglycolic anhydride (6CI);3-Oxaglutaricanhydride;Acetic acid, 2,2'-oxybis-, cyclic anhydride;Oxydiacetic anhydride;p-Dioxane-2,6-dione;1,4-Dioxane-2,6-dione; |
EINECS: | 224-761-5 |
Density: | 1.423 g/cm3 |
Melting Point: | 92-93 °C(lit.) |
Boiling Point: | 241.9 °C at 760 mmHg |
Flash Point: | 105.7 °C |
Appearance: | COA |
Hazard Symbols: | Xi |
Risk Codes: | 36/37/38 |
Safety: | 26-36-24/25 |
PSA: | 52.60000 |
LogP: | -0.91360 |
Conditions | Yield |
---|---|
With oxalyl dichloride; N,N-dimethyl-formamide In toluene for 3h; Inert atmosphere; Reflux; | 93% |
With phosphoric acid; acetic anhydride at 145℃; for 2h; Temperature; | 90% |
With niobium(V) oxide hydrate In o-xylene at 160℃; for 72h; Inert atmosphere; Molecular sieve; | 86% |
1,4-dioxane-2,6-dione
2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethylamine
17-azido-5-oxo-6-aza-3,9,12,15-tetraoxaheptadecanoic acid
Conditions | Yield |
---|---|
In dichloromethane | 100% |
In dichloromethane at 25℃; for 36h; | 98% |
In dichloromethane at 25℃; for 26h; | 98% |
In dichloromethane | |
In dichloromethane |
1,4-dioxane-2,6-dione
1,3,4,6-tetra-O-benzyl-2-deoxy-2-diglycolylimido-β-D-glucopyranoside
Conditions | Yield |
---|---|
With pyridine; acetic anhydride; triethylamine at 20 - 80℃; for 6.5h; | 100% |
1,4-dioxane-2,6-dione
5-(4-aminophenyl)-10,15,20-triphenylporphyrin
Conditions | Yield |
---|---|
In N,N-dimethyl-formamide at 20℃; for 24h; | 100% |
In N,N-dimethyl-formamide at 20℃; | 98% |
1,4-dioxane-2,6-dione
3-(<(4-methoxyphenyl)diphenylmethyl>amino)propanol
2-[({3-[((4-methoxyphenyl)diphenylmethyl)amino]propyl}oxycarbonyl)methoxy]acetic Acid, Triethylammonium Salt
Conditions | Yield |
---|---|
With triethylamine In dichloromethane for 2h; | 100% |
Conditions | Yield |
---|---|
In tetrahydrofuran for 18h; | 100% |
In tetrahydrofuran at 20℃; | |
In tetrahydrofuran for 18h; | 6.34 g |
1,4-dioxane-2,6-dione
heptane-1,7-diamine
{[7-(2-carboxymethoxyacetylamino)heptylaminocarbonyl]methoxy}acetic acid
Conditions | Yield |
---|---|
In N,N-dimethyl-formamide at 20℃; | 100% |
In tetrahydrofuran at 0 - 20℃; | 96% |
In tetrahydrofuran at 0 - 20℃; | 96% |
1,4-dioxane-2,6-dione
5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(piperidin-4-yl)-1H-pyrazole-3-carboxamide
2-(2-(4-(5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamido)piperidin-1-yl)-2-oxoethoxy)acetic acid
Conditions | Yield |
---|---|
With pyridine In dichloromethane at 20℃; | 100% |
1,4-dioxane-2,6-dione
5-tert-butoxycarbonylamino-1-aminopentane
2,2-dimethyl-4,12-dioxo-3,14-dioxa-5,11-diazahexadecan-16-oic acid
Conditions | Yield |
---|---|
In tetrahydrofuran at -50 - 20℃; for 21h; | 100% |
1,4-dioxane-2,6-dione
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 20℃; for 15h; Inert atmosphere; | 100% |
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The CAS registry number of Diglycolic anhydride is 4480-83-5. Its EINECS registry number is 224-761-5. The IUPAC name is 1,4-dioxane-2,6-dione. In addition, the molecular formula is C4H4O4 and the molecular weight is 116.07. It is also called 3-Oxaglutaricanhydride. What's more, it belongs to the classes of Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts; Dioxanes; Dioxanes Dioxolanes and should be stored in a cool and dry place.
The properties of the chemical are: (1)ACD/LogP: -2.06; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -2.06; (4)ACD/LogD (pH 7.4): -2.06; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 1.81; (8)ACD/KOC (pH 7.4): 1.81; (9)#H bond acceptors: 4; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 0; (12)Polar Surface Area: 52.6 Å2; (13)Index of Refraction: 1.45; (14)Molar Refractivity: 21.91 cm3; (15)Molar Volume: 81.5 cm3; (16)Polarizability: 8.68×10-24cm3; (17)Surface Tension: 45.3 dyne/cm; (18)Enthalpy of Vaporization: 47.88 kJ/mol; (19)Vapour Pressure: 0.0351 mmHg at 25°C.
Uses of Diglycolic anhydride: it can react with diethylamine to prepare N,N-Diethyldiglycollamsaeure. This reaction needs solvent CH2Cl2. The reaction time is 2 hours by heating. The yield is 81%.
When you are using this chemical, please be cautious about it as the following:
This chemical is not only irritating to skin, but also irritating to eyes and respiratory system. During using it, you should wear suitable protective clothing and should avoid this chemical contact with skin and eyes. In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice.
You can still convert the following datas into molecular structure:
(1)SMILES: O=C1OC(=O)COC1
(2)InChI: InChI=1/C4H4O4/c5-3-1-7-2-4(6)8-3/h1-2H2
(3)InChIKey: PIYNUZCGMLCXKJ-UHFFFAOYAT