Products Categories
CAS No.: | 45754-12-9 |
---|---|
Name: | 2,3-BIS(CHLOROMETHYL)PYRIDINE |
Article Data: | 9 |
Molecular Structure: | |
Formula: | C7H7 Cl2 N |
Molecular Weight: | 176.045 |
Synonyms: | 2,3-Bis(chloromethyl)pyridine; |
Density: | 1.275 g/cm3 |
Boiling Point: | 264.48 ºC at 760 mmHg |
Flash Point: | 139.294 ºC |
PSA: | 12.89000 |
LogP: | 2.55920 |
2,3-bis(hydroxymethyl)pyridine hydrochloride
2,3-bis(chloromethyl)-pyridine
Conditions | Yield |
---|---|
With thionyl chloride In toluene | 89% |
2,3-bis(hydroxymethyl)pyridine
2,3-bis(chloromethyl)-pyridine
Conditions | Yield |
---|---|
With thionyl chloride In dichloromethane at 45℃; Cooling with ice; | 40% |
With thionyl chloride In dichloromethane at 75℃; for 1h; | 26% |
With thionyl chloride In dichloromethane Heating / reflux; | 24% |
2,3-diethyl pyridinedicarboxylate
2,3-bis(chloromethyl)-pyridine
Conditions | Yield |
---|---|
With lithium aluminium tetrahydride; diethyl ether Erwaermen des Reaktionsprodukts mit Thionylchlorid; |
Pyridine-2,3-dicarboxylic acid
2,3-bis(chloromethyl)-pyridine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 72 percent / conc. H2SO4 / 20 h / Heating 2: 85 percent / NaBH4 / ethanol / 17 h / Heating 3: 26 percent / SOCl2 / CH2Cl2 / 1 h / 75 °C View Scheme | |
Multi-step reaction with 3 steps 1: sulfuric acid 2: sodium tetrahydroborate; hydrogenchloride / ethanol 3: thionyl chloride / toluene View Scheme | |
Multi-step reaction with 3 steps 1: thionyl chloride / Heating / reflux 2: sodium tetrahydroborate / ethanol; water / 20 °C 3: thionyl chloride / dichloromethane / Heating / reflux View Scheme |
dimethyl 2,3-pyridinedicarboxylate
2,3-bis(chloromethyl)-pyridine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 85 percent / NaBH4 / ethanol / 17 h / Heating 2: 26 percent / SOCl2 / CH2Cl2 / 1 h / 75 °C View Scheme | |
Multi-step reaction with 2 steps 1: sodium tetrahydroborate; hydrogenchloride / ethanol 2: thionyl chloride / toluene View Scheme | |
Multi-step reaction with 2 steps 1: sodium tetrahydroborate / ethanol; water / 20 °C 2: thionyl chloride / dichloromethane / Heating / reflux View Scheme | |
Multi-step reaction with 2 steps 1: sodium tetrahydroborate / ethanol / 80 °C / Cooling with ice 2: thionyl chloride / dichloromethane / 45 °C / Cooling with ice View Scheme |
2,3-Lutidine
2,3-bis(chloromethyl)-pyridine
2,3-bis(chloromethyl)pyridine hydrochloride
2,3-bis(chloromethyl)-pyridine
Conditions | Yield |
---|---|
With sodium carbonate In dichloromethane; water pH=7.5 - 8; |
Conditions | Yield |
---|---|
Stage #1: trimethylsilyl cyanide With cesium fluoride In acetonitrile at 10 - 20℃; for 0.5h; Stage #2: 2,3-bis(chloromethyl)-pyridine In acetonitrile at 10 - 40℃; for 12h; Temperature; Reagent/catalyst; | 98.6% |
2,3-bis(chloromethyl)-pyridine
sodium p-toluenesulfonamide
6-(toluene-4-sulfonyl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine
Conditions | Yield |
---|---|
In N,N-dimethyl-formamide at 70 - 80℃; for 2.5h; | 80.5% |
2,3-bis(chloromethyl)-pyridine
N-(((1S,9aS)-7-amino-3-oxo-1,3,9,9a-tetrahydrooxazolo[3,4-a]indol-1-yl)methyl)acetamide
N-(((1S,9aS)-3-oxo-7-(5H-pyrrolo[3,4-b]pyridin-6(7H)-yl)-1,3,9,9a-tetrahydrooxazolo[3,4-a]indol-1-yl)methyl)acetamide
Conditions | Yield |
---|---|
With potassium carbonate; potassium iodide In N,N-dimethyl-formamide at 80 - 90℃; | 80% |
What can I do for you?
Get Best Price
The Pyridine,2,3-bis(chloromethyl)-, with the cas registry number 45754-12-9, has the systematic name of 2,3-bis(chloromethyl)pyridine.
The characteristics of this kind of chemical are as follows: (1)ACD/LogP: 1.76; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 1; (4)ACD/LogD (pH 7.4): 1; (5)ACD/BCF (pH 5.5): 5; (6)ACD/BCF (pH 7.4): 5; (7)ACD/KOC (pH 5.5): 114; (8)ACD/KOC (pH 7.4): 115; (9)#H bond acceptors: 1; (10)#Freely Rotating Bonds: 2; (11)Polar Surface Area: 12.89; (12)Index of Refraction: 1.548; (13)Molar Refractivity: 43.875 cm3; (14)Molar Volume: 138.047 cm3; (15)Polarizability: 17.394 ×10-24 cm3; (16)Surface Tension: 42.237 dyne/cm; (17)Density: 1.275 g/cm3; (18)Flash Point: 139.294 °C; (19)Enthalpy of Vaporization: 48.21 kJ/mol; (20)Boiling Point: 264.48 °C at 760 mmHg; (21)Vapour Pressure: 0.016 mmHg at 25°C.
Additionally, the following datas could be converted into the molecular structure:
(1)SMILES:ClCc1ncccc1CCl
(2)InChI:InChI=1/C7H7Cl2N/c8-4-6-2-1-3-10-7(6)5-9/h1-3H,4-5H2
(3)InChIKey:FDHDTLFJPYRSBM-UHFFFAOYAK