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Detail of "478-43-3"

  • MSDS Download
  • CAS Number:
  • 478-43-3
  • Name:
  • Rhein

  • Molecular Structure:
  • Formula:
  • C15H8O6
  • Molecular Weight:
  • 284.22 .
  • Synonyms:
  • Monorhein;4,5-DiOH-anthraquinone-2-COOH;Chrysazin-3-carboxylic acid;Rhein (1,8-dihydroxy-3-carboxyl anthraquinone);4, 5-Dihydroxyanthraquinone-2-carboxylic acid;Rheic acid;9,10-Dihydro-4,5-dihydroxy-9,10-dioxo-2-anthracene carboxylic acid;Rhubarb Yellow;1.8-Dihydroxy-3-Carboxy anthraquinone;4-10-00-04088 (Beilstein Handbook Reference);2-Anthroic acid, 9,10-dihydro-4,5-dihydroxy-9,10-dioxo- (8CI);4,5-dihydroxy-9,10-dioxo-anthracene-2-carboxylate;Cassic acid;2-Anthroic acid, 9,10-dihydro-4,5-dihydroxy-9,10-dioxo-;2-Anthracenecarboxylic acid, 9,10-dihydro-4,5-dihydroxy-9,10-dioxo-;1,8-Dihydroxyanthraquinone-3-carboxylic acid;9,10-Dihydro-4,5-dihydroxy-9,10-dioxo-2-anthracenecarboxylic acid;4,5-Dihydroxy-2-anthraquinonecarboxylic acid;
  • EINECS:
  • 207-521-4
  • Density:
  • 1.687 g/cm3
  • Melting Point:
  • ≥300 °C(lit.)
  • Boiling Point:
  • 597.8 °C at 760 mmHg
  • Flash Point:
  • 329.4 °C
  • Solubility:
  • <0.1 g/100 mL at 17 °C in water
  • Appearance:
  • Yellowish brown solid
  • Hazard Symbols:
  • IrritantXi
  • Risk Codes:
  • 36/37/38
  • Safety:
  • 26-37/39 Details

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CAS No.478-43-3 Rhein

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Specifications Molecular formula: C15H8O6 Molecular weight: 284.21 Natural Rhein 99.0% HPLC,Isolated from Rheum palmatum L

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CAS No.478-43-3 Rhein

Gladys Mechanism of action of anthraquinone-type laxatives in the rat Mechanism of action of anthraquinone-type laxatives in the rat. Leng-Peschlow, Elke (Abt. Pharmakol., Madaus G.m.b.H. and Co., Cologne, Fed. Rep. Ger.). DTW, Dtsch. Tieraerztl. Wochenschr., 94(1), 15-18 (Germ

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Molecular Weight: 284.22

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TOXICITY: SAFETY: Production: Others: Rhein PCM-RO-002-020 – 20mg PCM-RO-002-100 – 100mg CAS: 478-43-3 Marker For: Rheum officinale Baill. Molecular Formula C15H8O6

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CAS No.478-43-3 Rhein

Product Name: Rhein Specification: 98% Test method: By HPLC CAS Registry Number: 478-43-3 Molecular Formula: C15H8O6 Molecular Weight: 284.22 Molecular structure: Biological Source: Isol. From Polygonum cuspidatum Physical Description: Orange or yellow-brown needl

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CAS No.478-43-3 Rhein

Rhein(Monorhein; NSC 38629; Rheic acid; Rheinic acid) is a constituent of rhubarb which was isolated from the fresh rhizome of Rheum coreanum Nakai.

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CAS No.478-43-3 Rhein

Rhein 90% 95% 98% 99%CAS No. 478-43-3 [Herb source]: Rheum palmatum L,rhe root [Molecular Formula]: C15H8O6; [Molecular Weight]: 284.21 [Physics Properties]:Yellow needle cystal,melting point 321-322 OC,decompose on 330 OC.hardly soluble in the water,soluble in the alkali etc,s

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CAS No.478-43-3 Rhein

PRODUCT NAME Rhein CAS NO. 478-43-3 CHEMICAL NAME 1.8-Dihydroxy-3-carboxy-anthraquinone EXTRACT ORIGIN Rheum palmatum Rheum palmatum L roots APPEARANCE Brown needle crystal, yellow needle crystals after sublimation SPECIFICATION

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CAS No.478-43-3 Rhein

Rhein, a main constituent of rhubarb, is a well-characterized anti-inflammatory agent with recognized utility in a range of inflammatory diseases such as ostarthritis, diabetic nephropathy etc. Rhein is also known to inhibit superoxide anion production, chemotaxis, phagocytic act

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Yellow powder Description: Used in health food and medicament

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Chrysazin-3-carboxylic acid

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RHEIN

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Reference

Mechanism of action of anthraquinone-type laxatives in the rat
Mechanism of action of anthraquinone-type laxatives in the rat. Leng-Peschlow, Elke (Abt. Pharmakol., Madaus G.m.b.H. and Co., Cologne, Fed. Rep. Ger.). DTW, Dtsch. Tieraerztl. Wochenschr., 94(1), 15-18 (German) 1987. CODEN: DDTWDG. ISSN: 0341-6593. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Sennoside A [81-27-6], sennoside B [128-57-4], their aglycon metabolite rhein (I) [478-43-3], and the synthetic anthraquinone danthron (II) [117-10-2] were studied for their laxative mechanism on the isolated rat colon and in rats. 84-65-1 and 117-10-2 which are cas registry numbers of chemicals are mentioned. With oral administration, I and II had a pronounced laxative effect only at 10-fold higher doses than those of the sennosides, probably because a higher absorbability of the aglycons prevented a local action in the colon. After intracecal administration, the sennosides and I accelerated large-intestinal transit, whereas II did not. Net fluid absorption by the perfused colon was inhibited by oral pretreatment with the sennosides, but not by their local perfusion. I, however, was active by local perfusion. The sennosides are apparently colon specific and exert their laxative effect primarily via changes in colonic motility and, in addn., via changes in absorption mechanisms. As II has only a weak effect on large-intestinal transit, its laxative effect may be mainly due to inhibition of fluid absorption or activation of secretory processes. .
The detection of laxative abuse
The detection of laxative abuse. Morton, John (Dep. Chem. Pathol., London Hosp., London E1 1BB, UK). Ann. Clin.Several reagents with their cas registry numbers 603-50-9 and 77-09-8 are used here. Biochem., 24(1), 107-8 (English) 1987. CODEN: ACBOBU. ISSN: 0004-5632. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The abuse of the laxatives bisacodyl [603-50-9], phenolphthalein [77-09-8], rhein [478-43-3], and danthron [117-10-2] was detected by identifying these drugs in the urine and feces collected from subjects. The laxatives in the urine or feces were hydrolyzed (no hydrolysis for fecal samples) extd. with suitable solvents, and identified by thin-layer chromatog.; all the laxatives tested could be detected in the urine from a single tablet dose. .
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