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CAS No.: | 496-67-3 |
---|---|
Name: | Bromisoval |
Molecular Structure: | |
Formula: | C6H11BrN2O2 |
Molecular Weight: | 223.07 |
Synonyms: | Urea,(2-bromo-3-methylbutyryl)- (6CI,8CI);(RS)-2-Bromoisovalerylurea;(a-Bromoisovaleryl)urea;2-Bromo-3-methylbutyrylurea;2-Bromoisovalerylurea;Abroval;Alluval;Alural;BVU;Bromaral;Bromcarbamide;Bromisovalerylurea;Bromisovalum;Bromizoval;Bromocarbamide;Bromoisovalum;Bromovaleroylurea;Bromovalerylurea;Bromoxil;Bromuvan;Bromvalerylurea;Brovalin;Brovalurea;Calmotin;Dagrabromyl;Dormigene;Isobromyl;Pivadorm;Pivadorn;Upiol;a-Bromo-b-dimethylpropanoylurea;a-Bromoisovaleric acid ureide;a-Bromoisovaleroylurea; |
EINECS: | 207-825-7 |
Density: | 1.504 g/cm3 |
Melting Point: | 152 °C |
Solubility: | 19.03g/L(temperature not stated) |
PSA: | 72.19000 |
LogP: | 1.69200 |
2-bromoisovaleryl chloride
urea
bromisoval
Conditions | Yield |
---|---|
at 35 - 40℃; for 6h; Time; | 86% |
N-(α-bromo-isovaleryl)-O-methyl-isourea
bromisoval
Conditions | Yield |
---|---|
With hydrogenchloride |
bromisoval
Conditions | Yield |
---|---|
With hydrogenchloride |
bromisoval
Conditions | Yield |
---|---|
With sodium hydroxide |
Conditions | Yield |
---|---|
With Petroleum ether und Behandeln des entstandenen <α-Brom-isovaleryl>-isocyanats mit Ammoniak; |
hydrogenchloride
N-(α-bromo-isovaleryl)-O-methyl-isourea
A
methylene chloride
B
bromisoval
2-bromo-3-methyl-butyryl bromide
bromisoval
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: water; benzene; NaOH-solution 2: hydrochloric acid View Scheme | |
Multi-step reaction with 2 steps 1: diethyl ether 2: hydrochloric acid View Scheme |
IUPAC Name: Bromisoval [INN]
The MF of Bromisoval [INN] (496-67-3) is C6H11BrN2O2.
The MW of Bromisoval [INN] (496-67-3) is 223.07.
Synonyms of Bromisoval [INN] (496-67-3): Rarechem ax ki 5046 ; 1-(2-Bromoisovaleryl)urea ; A-(Bromoisovaleryl)urea ; Alpha(bromoisovaleryl)urea ; Labotest-bb lt00134620 ; Bromovalerylurea ; Bromoisovalerylurea ; Bromo-iso-valerylurea (alpha)
Index of Refraction: 1.514
EINECS: 207-825-7
Density: 1.504 g/ml
Melting point: 152 °C
Merck: 1397
Bromisoval [INN] (496-67-3) has a mild sedative and hypnotic effects, serving markedly after 5 minutes.Eeffect last for 4 hours, no habit.Can be made into powder, tablets and injections.
With isoamyl alcohol as raw material, the first oxidation of isovalerate, and then brominated to α-bromo-isovaleryl bromide and finally generate the bromine and urea condensation of iso-amyl urea.
1. | orl-wmn TDLo:400 mg/kg:CNS | BMJOAE British Medical Journal. 1 (1955),1238. | ||
2. | orl-hmn LDLo:57 mg/kg | TOIZAG Toho Igakkai Zasshi. Journal of Medical Society of Toho University. 7 (1960),513. | ||
3. | orl-rat LD50:1000 mg/kg | FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. 7 (1948),262. | ||
4. | orl-mus LD50:2 g/kg | OYYAA2 Oyo Yakuri. Pharmacometrics. 11 (1976),693. | ||
5. | orl-cat LD50:450 mg/kg | NIIRDN “Drugs in Japan. Ethical Drugs, 6th Edition 1982“ Edited by Japan Pharmaceutical Information Center. 6 (1982),738. | ||
6. | orl-rbt LD50:1200 mg/kg | MEIEDD Merck Index. 10 (1983),193. |
Reported in EPA TSCA Inventory.
Moderately toxic by ingestion. Human systemic effects by ingestion: nausea or vomiting, and coma. A sedative and hypnotic agent. When heated to decomposition it emits very toxic fumes of Br− and NOx.Safety information of Bromisoval [INN] (496-67-3):
RTECS YS3150000