Reference

Increased adrenal catecholamines in salt-sensitive genetically hypertensive Dahl rats

Increased adrenal catecholamines in salt-sensitive genetically hypertensive Dahl rats. Saavedra, Juan M.; Del Carmine, Renata; McCarty, Richard; Guicheney, Pascale; Weise, Virginia; Iwai, Junichi (Lab. Clin. Sci., Natl.Chemicals with cas numbers 51-41-2 and 9037-68-7 also play role. Inst. Ment. Health, Bethesda, MD 20205, USA). Am. J. Physiol., 245(5, Pt. 1), H762-H766 (English) 1983. CODEN: AJPHAP. ISSN: 0002-9513. DOCUMENT TYPE: Journal CA Section: 14 (Mammalian Pathological Biochemistry) Section cross-reference(s): 18 Catecholamine levels and activity of catecholamine-forming enzymes have been quantitated in adrenal glands of Dahl Na-resistant (R) and Na-sensitive (S), genetically hypertensive rats maintained on low- or high-salt diets. A high-salt diet results in markedly different changes in the catecholamine metab. in R and S rats. In R rats, a high-salt diet reduces the activities of tyrosine 3-hydroxylase (TH; -5%) and dopamine b-hydroxylase (DBH; -18%) as well as the levels of all catecholamines (dopamine -28%, norepinephrine -11%; and epinephrine -28%). In contrast, S rats fed a high-salt diet showed increased TH (+7%) and phenylethanolamine N-methyltransferase (+16%) activities as well as an increased content of adrenal norepinephrine (+13%) and epinephrine (+21%). These findings demonstrate a genetic difference in the effects of a high-salt diet on the synthesis of catecholamines in the adrenal gland of Dahl R and S rats. Hypertension only occurs in S rats on a high-salt diet, concomitant with large increases in the formation of adrenal catecholamines. .

Effect of a vasopressin analog on chemoreactive properties of sensorimotor cortical neurons

Effect of a vasopressin analog on chemoreactive properties of sensorimotor cortical neurons. Kruglikov, R. I.; Brodskii, B. L.; Koshtoyants, O. Kh.; Markarova, M. Yu.; Cipens, G.; Papsuevich, O. S. (Inst.Several reagents with their cas registry numbers 51-41-2 and 51-84-3 are used here. Higher Nerv. Act. Neurophysiol., Moscow, USSR). Byull. Eksp. Biol. Med., 96(10), 3-5 (Russian) 1983. CODEN: BEBMAE. ISSN: 0365-9615. DOCUMENT TYPE: Journal CA Section: 2 (Mammalian Hormones) Deglycylarginine vasopressin [37552-33-3] (10 mg/kg) injected s.c. into rats did not affect the mean frequency of background unit activity of sensorimotor cortex neurons. However, it did alter the pattern of impulse activity. It also altered the responses of sensorimotor cortex neurons to acetylcholine [51-84-3] and esp. to noradrenaline [51-41-2]. These changes in the chemoreactive properties of sensorimotor cortex neurons induced by the vasopressin analog may underlie its effect on learning and memory. .