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| CAS No.: | 520-85-4 |
|---|---|
| Name: | MEDROXYPROGESTERONE |
| Molecular Structure: | |
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| Formula: | C22H32 O3 |
| Molecular Weight: | 344.494 |
| Synonyms: | Pregn-4-ene-3,20-dione,17-hydroxy-6a-methyl-(7CI,8CI); Progesterone, 17-hydroxy-6a-methyl- (6CI); 17-Hydroxy-6a-methylpregn-4-ene-3,20-dione;17-Hydroxy-6a-methylprogesterone;17a-Hydroxy-6a-methylprogesterone; 6a-Methyl-17-hydroxyprogesterone; 6a-Methyl-17R-hydroxyprogesterone;6a-Methyl-17a-hydroxypregn-4-ene-3,20-dione; 6a-Methyl-17a-hydroxyprogesterone; 6a-Methyl-4-pregnen-17a-ol-3,20-dione;Medoxyprogesterone; Medroxyprogesteron; Medroxyprogesterone; NSC 27408; U 8840 |
| Density: | 1.13g/cm3 |
| Melting Point: | 204-206°C |
| Boiling Point: | 488°Cat760mmHg |
| Flash Point: | 263°C |
| Hazard Symbols: | Xn |
| Risk Codes: | 48-63-68 |
| Safety: | An experimental teratogen. Experimental reproductive effects. A steroid. When heated to decomposition it emits acrid smoke and irritating fumes. |
| PSA: | 54.37000 |
| LogP: | 4.08440 |
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| Conditions | Yield |
|---|---|
| With potassium hydroxide | |
| With water; sodium hydroxide In methanol for 5h; Reflux; |
- 80996-18-5
17-hydroxy-6β-methyl-pregn-4-ene-3,20-dione
- 520-85-4
Medroxyprogesterone
| Conditions | Yield |
|---|---|
| With hydrogenchloride; chloroform |
- 23706-51-6
5,17-dihydroxy-6β-methyl-5α-pregnane-3,20-dione
- 520-85-4
Medroxyprogesterone
| Conditions | Yield |
|---|---|
| With hydrogenchloride; chloroform | |
| With hydrogenchloride | |
| Multi-step reaction with 2 steps 1: pyridine; aq. NaOH solution 2: HCl; CHCl3 View Scheme |
- 115459-59-1
16β-bromo-17-hydroxy-6α-methyl-pregn-4-ene-3,20-dione
- 520-85-4
Medroxyprogesterone
| Conditions | Yield |
|---|---|
| With methanol; nickel |
| Conditions | Yield |
|---|---|
| Multi-step reaction with 6 steps 1: benzene; toluene-4-sulfonic acid 2: peroxybenzoic acid; chloroform 3: benzene; diethyl ether 4: aqueous methanol.H2SO4 5: CrO3; pyridine 6: aqueous HCl View Scheme |
- 113665-92-2
3β,5,17-trihydroxy-6β-methyl-5α-pregnan-20-one
- 520-85-4
Medroxyprogesterone
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: CrO3; pyridine 2: aqueous HCl View Scheme |
- 19699-76-4
20,20-ethanediyldioxy-6β-methyl-5α-pregnane-3β,5,17-triol
- 520-85-4
Medroxyprogesterone
| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 1: aqueous methanol.H2SO4 2: CrO3; pyridine 3: aqueous HCl View Scheme |
- 19699-74-2
3β-acetoxy-20,20-ethanediyldioxy-pregn-5-en-17-ol
- 520-85-4
Medroxyprogesterone
| Conditions | Yield |
|---|---|
| Multi-step reaction with 5 steps 1: peroxybenzoic acid; chloroform 2: benzene; diethyl ether 3: aqueous methanol.H2SO4 4: CrO3; pyridine 5: aqueous HCl View Scheme |
- 19699-75-3
3β-acetoxy-20,20-ethanediyldioxy-5,6α-epoxy-5α-pregnan-17-ol
- 520-85-4
Medroxyprogesterone
| Conditions | Yield |
|---|---|
| Multi-step reaction with 4 steps 1: benzene; diethyl ether 2: aqueous methanol.H2SO4 3: CrO3; pyridine 4: aqueous HCl View Scheme |
- 103050-56-2
3β-acetoxy-5,6α-epoxy-17ξ-((Ξ)-tetrahydropyran-2-yloxy)-5α-androstane-17ξ-carbonitrile
- 520-85-4
Medroxyprogesterone
| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 1: anisole; diethyl ether 2: CrO3; pyridine 3: aqueous HCl View Scheme |
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Chemistry
Product Name: Medroxyprogesterone (CAS NO.520-85-4)
Molecular Formula: C22H32O3
Molecular Weight: 344.49g/mol
Mol File: 520-85-4.mol
Einecs: 208-298-6
Boiling point: 488 °C at 760 mmHg
Flash Point: 263 °C
Density: 1.13 g/cm3
Surface Tension: 45.1 dyne/cm
Enthalpy of Vaporization: 86.88 kJ/mol
Vapour Pressure: 1.43E-11 mmHg at 25°C
XLogP3-AA: 3.5
H-Bond Donor: 1
H-Bond Acceptor: 3
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| women | TDLo | parenteral | 6mg/kg/13W-I (6mg/kg) | PERIPHERAL NERVE AND SENSATION: SENSORY CHANGE INVOLVING PERIPHERAL NERVE BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | Medical Journal of Australia. Vol. 163, Pg. 51, 1995. |
Safety Profile
An experimental teratogen. Experimental reproductive effects. A steroid. When heated to decomposition it emits acrid smoke and irritating fumes.
Safety Information of Medroxyprogesterone (CAS NO.520-85-4):
Hazard Codes: Xn.gif){kind=small}
Risk Statements: 48-63-68
48: Danger of serious damage to health by prolonged exposure
63: Possible risk of harm to the unborn child
68: Possible risk of irreversible effects
Safety Statements: 22-24/25
22: Do not breathe dust
24: Avoid contact with skin
25: Avoid contact with eyes
Specification
Medroxyprogesterone ,its CAS NO. is 520-85-4,the synonyms is Methyloxyprogesterone ; Hydroxymethylprogesterone ; 17Alpha-hydroxy-6alpha-methyl-4-pregnene-3,20-dione ; 17Alpha-hydroxy-6alpha-methylprogesterone ; 6-Dihydromegestrol ; 6Alpha-methyl-17alpha-hydroxy-progesterone ; 6-Alpha-methyl-17-hydroprogesterone .