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CAS No.: | 52434-75-0 |
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Name: | LHRH (1-5) |
Article Data: | 3 |
Molecular Structure: | |
Formula: | C34H38 N8 O9 |
Molecular Weight: | 702.724 |
Synonyms: | L-Tyrosine,N-[N-[N-[N-(5-oxo-L-prolyl)-L-histidyl]-L-tryptophyl]-L-seryl]- |
PSA: | 267.73000 |
LogP: | 0.81160 |
L-pyroglutamyl-L-histidyl-L-trypthophyl-L-seryl-L-tyrosine tert-butyl ester
pGlu-His-Trp-Ser-Tyr
Conditions | Yield |
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With methoxybenzene; trifluoroacetic acid at 0℃; for 3h; |
O-benzyl-N-tert-butoxycarbonyl-L-tyrosine
BOC-O-benzyl-L-serine
Boc-Trp-OH
Boc-His(Dnp)-OH
pGlu-His-Trp-Ser-Tyr
Conditions | Yield |
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Yield given. Multistep reaction; |
Tyr(tBu)
pGlu-His-Trp-Ser-Tyr
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 78 percent / dioxane / 5 h / papain, dithioerythritol in phosphate buffer, pH 9 2: deprotection 3: 67 percent / methanol; H2O / 16 h / Ambient temperature; papain, dithioerythritol, pH 8 4: TFA, anisole / 3 h / 0 °C View Scheme |
L-seryl-L-tyrosine tert-butyl ester
pGlu-His-Trp-Ser-Tyr
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 67 percent / methanol; H2O / 16 h / Ambient temperature; papain, dithioerythritol, pH 8 2: TFA, anisole / 3 h / 0 °C View Scheme |
N-benzyloxycarbonyl-L-seryl-L-tyrosine tert-butyl ester
pGlu-His-Trp-Ser-Tyr
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: deprotection 2: 67 percent / methanol; H2O / 16 h / Ambient temperature; papain, dithioerythritol, pH 8 3: TFA, anisole / 3 h / 0 °C View Scheme |
L-Pyroglutamyl-L-histidine Methyl Ester
pGlu-His-Trp-Ser-Tyr
Conditions | Yield |
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Multi-step reaction with 3 steps 1: 75 percent / CH2Cl2; H2O / 16 h / Ambient temperature; α-chymotrypsin 2: 67 percent / methanol; H2O / 16 h / Ambient temperature; papain, dithioerythritol, pH 8 3: TFA, anisole / 3 h / 0 °C View Scheme |
L-tryptophanamide
pGlu-His-Trp-Ser-Tyr
Conditions | Yield |
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Multi-step reaction with 3 steps 1: 75 percent / CH2Cl2; H2O / 16 h / Ambient temperature; α-chymotrypsin 2: 67 percent / methanol; H2O / 16 h / Ambient temperature; papain, dithioerythritol, pH 8 3: TFA, anisole / 3 h / 0 °C View Scheme |
L-pyroglutamyl-L-histidine-L-tryptophane amide
pGlu-His-Trp-Ser-Tyr
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 67 percent / methanol; H2O / 16 h / Ambient temperature; papain, dithioerythritol, pH 8 2: TFA, anisole / 3 h / 0 °C View Scheme |
methanol
pGlu-His-Trp-Ser-Tyr
L-pyroglutamyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosine methyl ester
Conditions | Yield |
---|---|
With boron trifluoride at 0℃; for 8h; | 83% |
pGlu-His-Trp-Ser-Tyr
(S)-2-{(S)-3-Hydroxy-2-[(Z)-2-{(S)-3-(1H-imidazol-4-yl)-2-[((S)-5-oxo-pyrrolidine-2-carbonyl)-amino]-propionylamino}-3-(1H-indol-3-yl)-acryloylamino]-propionylamino}-3-(4-hydroxy-phenyl)-propionic acid
Conditions | Yield |
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With (S)-tryptophan 2',3'-oxidase from Chromobacterium violaceum (ATCC 12472) In various solvent(s) at 30℃; for 20h; | 66% |