Reference

New method for the synthesis of 2-thiophenecarboxylic acids in the presence of V-, Fe-, or Mo-containing catalysts

New method for the synthesis of 2-thiophenecarboxylic acids in the presence of V-, Fe-, or Mo-containing catalysts. Khusnutdinov, Ravil I.; Shchadneva, Nina A.; Bayguzina, Alfia R. 3153-26-2 are also occured in this study.; Mayakova, Yulia Yu.; Smirnov, Anton A.; Burangulova, Rita Yu.; Dzhemilev, Usein M. (Institute of Petrochemistry and Catalysis, Bashkortostan Republic Academy of Sciences, Ufa Scientific Centre, Russian Academy of Sciences, Ufa 450075, Russia). ARKIVOC (Gainesville, FL, United States), (11), 53-60 (English) 2004 Arkat USA Inc. URL: http://www.arkat-usa.org/ark/journal/2004/I11_Chupakhin/OC-1176H/1 176.pdf. CODEN: AGFUAR.In this article, certain chemicals are used. One of their cas registry numbers is 3153-26-2 DOCUMENT TYPE: Journal; (online computer file) CA Section: 27 (Heterocyclic Compounds (One Hetero Atom)) 2-Thiophenecarboxylic acid and its derivs. were synthesized by the reaction of thiophenes with the CCl4-CH3OH-catalyst system in total yields of 44-85%. The probable scheme of the reaction involves successive oxidn. of methanol with tetrachloromethane to Me hypochlorite and formaldehyde. Under the action of the latter, thiophene undergoes oxymethylation, giving rise to 2-oxymethylthiophene, which is oxidized with CH3OCl to 2-thiophenecarboxylic acid. In the presence of an excess of CH3OH, the latter is subjected to esterification. It was found that Fe(acac)3, VO(acac)2, and Mo(CO)6 are the catalysts of choice for this reaction. ..

Mutagenicity studies of selected antihistamines, their metabolites and products of nitrosation

Mutagenicity studies of selected antihistamines, their metabolites and products of nitrosation. Kammerer, R. C.; Froines, J. R.; Price, T. (Sch. Med., Univ. California, Los Angeles, CA 90024, USA). Food Chem. Toxicol., 24(9), 981-5 (English) 1986. CODEN: FCTOD7. ISSN: 0278-6915. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Methapyrilene [91-80-5], 4 structurally related antihistamines, 3 metabolites of methapyrilene, and products of the reaction of methapyrilene with nitrite were all tested for mutagenicity to Salmonella typhimurium. The 2 products of the methapyrilene-nitrite reaction have also been identified as metabolites of methapyrilene. None was mutagenic alone, either with or without rat liver S-9 activation. After reaction with NaNO2 in AcOH soln. (nitrosation), the products of 5 of the 10 compds. were mutagenic. These compds. were methaphenilene [493-78-7], 2-thiophenemethanol [636-72-6], 2-thiophenecarboxylic acid [527-72-0], N-(2-pyridyl)-N'N'-dimethylethylenediamine [23826-72-4] and N-(2-thenylmethyl)-2-aminopyridine [140-19-2].