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CAS No.: | 53-19-0 |
---|---|
Name: | Mitotan |
Article Data: | 12 |
Molecular Structure: | |
Formula: | C14H10Cl4 |
Molecular Weight: | 320.045 |
Synonyms: | 1,1-Dichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane;1-(2-Chlorophenyl)-1-(4-chlorophenyl)-2,2-dichloroethane;1-(o-Chlorophenyl)-1-(p-chlorophenyl)-2,2-dichloroethane;2,4'-Dichlorodiphenyldichloroethane;2-(p-Chlorophenyl)-2-(o-chlorophenyl)-1,1-dichloroethane;CB 313;Chloditan;Chlodithane;Lysodren;Mitotane;NSC 38721;Opeprim;o,p'-DDD;o,p'-Dichlorodiphenyldichloroethane;o,p'-TDE; |
EINECS: | 200-166-6 |
Density: | 1.372 g/cm3 |
Melting Point: | 77-78 °C(lit.) |
Boiling Point: | 398.9 °C at 760 mmHg |
Flash Point: | 194.2 °C |
Solubility: | <0.1 g/100 mL at 24℃ |
Appearance: | Crystalline Solid |
Hazard Symbols: | Xn |
Risk Codes: | 40 |
Safety: | 36/37 |
PSA: | 0.00000 |
LogP: | 5.92900 |
2,2‐dichloro‐1‐(2‐chlorophenyl)ethan‐1‐one
chlorobenzene
1,1-dichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane
Conditions | Yield |
---|---|
Stage #1: 2,2‐dichloro‐1‐(2‐chlorophenyl)ethan‐1‐one With sodium tetrahydroborate In methanol at 20℃; for 0.333333h; Schlenk technique; Inert atmosphere; Stage #2: chlorobenzene With sulfuric acid at 20℃; for 0.166667h; | 89% |
2,2-dichloro-1-(2-chlorophenyl)ethanol
chlorobenzene
1,1-dichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane
Conditions | Yield |
---|---|
With sulfuric acid at 35℃; for 6h; | 71% |
With sulfuric acid at 30 - 60℃; | |
With sulfuric acid; sulfur trioxide |
o,p'-DDT
A
1,1-dichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane
B
1-(4-chlorophenyl)-1-phenylethane
C
1-(o-chlorophenyl)-1-(p-chlorophenyl)ethane
D
1-(2-chloro-phenyl)-1-phenyl-ethane
Conditions | Yield |
---|---|
With hydrogen; triethylamine; palladium on activated charcoal In methanol at 20℃; for 0.166667h; | A 25% B n/a C 42% D n/a |
Conditions | Yield |
---|---|
With aluminium amalgam In ethanol |
o,p'-DDT
A
1-chloro-2-(2-chlorophenyl)-2-(4-chlorophenyl)ethane
B
1,1-dichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane
Conditions | Yield |
---|---|
With sodium tetrahydroborate In dimethyl sulfoxide |
sulfuric acid
2,2-dichloro-1-(2-chlorophenyl)ethanol
chlorobenzene
1,1-dichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane
Conditions | Yield |
---|---|
at 30 - 60℃; |
2-chlorophenylmagnesium bromide
1,1-dichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: diethyl ether 2: concentrated H2SO4 / 30 - 60 °C View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: H2SO4 View Scheme | |
Multi-step reaction with 2 steps 1: H2SO4 View Scheme |
2,2,2-trichloro-1-(2-chloro-phenyl)-ethanol
1,1-dichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: Al-Hg, iPrOH 2: SO3/H2SO4 View Scheme |
The Chlodithane is an organic compound with the formula C14H10Cl4. The IUPAC name of this chemical is 1-chloro-2-[2,2-dichloro-1-(4-chlorophenyl)ethyl]benzene. With the CAS registry number 53-19-0, it is also named as Benzene, 1-chloro-2-(2,2-dichloro-1-(4-chlorophenyl)ethyl)-. The product's categories are Organics; Intermediates & Fine Chemicals; Pharmaceuticals. Besides, it is a crystalline solid, which should be stored in a closed dark and dry place. It is used to treat pituitary-dependent Cushing's syndrome in canines. The medication is used in the controlled destruction of adrenal tissue, leading to a decrease in cortisol production.
Physical properties about Chlodithane are: (1)ACD/LogP: 5.39; (2)# of Rule of 5 Violations: 1; (3)ACD/LogD (pH 5.5): 5.39; (4)ACD/LogD (pH 7.4): 5.39; (5)ACD/BCF (pH 5.5): 7332.84; (6)ACD/BCF (pH 7.4): 7332.84; (7)ACD/KOC (pH 5.5): 20340.07; (8)ACD/KOC (pH 7.4): 20340.07; (9)#Freely Rotating Bonds: 3; (10)Index of Refraction: 1.599; (11)Molar Refractivity: 79.65 cm3; (12)Molar Volume: 233.1 cm3; (13)Polarizability: 31.57×10-24cm3; (14)Surface Tension: 44.6 dyne/cm; (15)Density: 1.372 g/cm3; (16)Flash Point: 194.2 °C; (17)Enthalpy of Vaporization: 62.42 kJ/mol; (18)Boiling Point: 398.9 °C at 760 mmHg; (19)Vapour Pressure: 3.28E-06 mmHg at 25°C.
Preparation: this chemical can be prepared by chlorobenzene and 2,2-dichloro-1-(2-chloro-phenyl)-ethanol. This reaction will need reagent concentrated H2SO4. The reaction temperature is 30 - 60 °C. The yield is about 78%.
Uses of Chlodithane: it can be used to produce (2-chloro-phenyl)-(4-chloro-phenyl)-methane by heating. It will need reagent KOH and solvent ethane-1,2-diol with reaction time of 6 hours. The yield is about 68%.
When you are using this chemical, please be cautious about it as the following:
It has limited evidence of a carcinogenic effect. When you are using it, wear suitable protective clothing and gloves.
You can still convert the following datas into molecular structure:
(1)SMILES: Clc1ccccc1C(c2ccc(Cl)cc2)C(Cl)Cl
(2)InChI: InChI=1/C14H10Cl4/c15-10-7-5-9(6-8-10)13(14(17)18)11-3-1-2-4-12(11)16/h1-8,13-14H
(3)InChIKey: JWBOIMRXGHLCPP-UHFFFAOYAD
(4)Std. InChI: InChI=1S/C14H10Cl4/c15-10-7-5-9(6-8-10)13(14(17)18)11-3-1-2-4-12(11)16/h1-8,13-14H
(5)Std. InChIKey: JWBOIMRXGHLCPP-UHFFFAOYSA-N
The toxicity data is as follows:
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
guinea pig | LD50 | oral | > 5gm/kg (5000mg/kg) | Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 26, Pg. 309, 1984. | |
man | TDLo | oral | 17gm/kg/35W (17000mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Cancer Vol. 42, Pg. 2177, 1978. |
mouse | LD50 | oral | > 4gm/kg (4000mg/kg) | Pharmaceutical Chemistry Journal Vol. 11, Pg. 1298, 1977. | |
rat | LD50 | oral | > 5gm/kg (5000mg/kg) | Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 26, Pg. 309, 1984. | |
women | TDLo | oral | 800mg/kg/4D (800mg/kg) | SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" | Cancer Vol. 42, Pg. 2177, 1978. |
women | TDLo | oral | 11gm/kg/15W (11000mg/kg) | VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION BLOOD: NORMOCYTIC ANEMIA BLOOD: PIGMENTED OR NUCLEATED RED BLLOD CELLS | Cancer Vol. 42, Pg. 2177, 1978. |
women | TDLo | oral | 14gm/kg/22W (14000mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" GASTROINTESTINAL: NAUSEA OR VOMITING | Cancer Vol. 42, Pg. 2177, 1978. |