Reference

Pharmaceutical preparations containing triazolopyrimidines

Pharmaceutical preparations containing triazolopyrimidines. Ganguly, Ashit K.; Peets, Edwin A.; Saksena, Anil K. (Scherico Ltd., Switz.). Ger. Offen. DE 2714263 13 Oct 1977, 24 pp. (German). (Germany). CODEN: GWXXBX.Several reagents such as 5413-85-4 is used here. CLASS: IC: A61K031-505. PRIORITY: US 76-673785 5 Apr 1976. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 28 V-triazolo[4,5-d]pyrimidines are prepd. and used in topical pharmaceutical compns. for treatment of psoriasis. For example, 5-amino-4,6-dichloropyrimidine [5413-85-4] was heated with cyclopentylamine [1003-03-8] in EtOH to give 5-amino-4-chloro-6-cyclopentylaminopyrimidine (I) [5452-43-7]. I was suspended in 2N AcOH and treated with NaNO2 to give 7-chloro-3-cyclopentyl-3H-v-triazolo[4,5-d]pyrimidine (II) [14054-48-9]. A salve was prepd. by dispersing 1-20.0 mg micronized II in a mixt. of 50.0 mg mineral oil and enough white petrolatum to give 1. 5413-85-4 is the cas registry number. This chemical is also mentioned in this article.0 g. ..

Carbocyclic arabinosyladenine, an adenosine deaminase resistant antiviral agent

Carbocyclic arabinosyladenine, an adenosine deaminase resistant antiviral agent. Vince, Robert; Daluge, Susan (Coll. Pharm., Univ. Minnesota, Minneapolis, Minn., USA). J. Med. 14036-06-7 and 62357-70-4 are also occured in this study. Chem., 20(4), 612-13 (English) 1977. CODEN: JMCMAR. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Section cross-reference(s): 33 Hydrolysis of epoxide (I) [62357-71-5] and acetylation gave a mixt. from which (.+-.)-4.alpha.-acetamido-2.beta.,3.alpha.-diacetoxy-1.alpha.-cyclopent ylmethyl acetate [62413-48-3] was sepd. and, after hydrolysis, condensed with 5-amino-4,6-dichloropyrimidine [5413-85-4], cyclized with diethoxymethyl acetate [14036-06-7] and aminated to give (.+-.)-9-[2.alpha.,3.beta.-dihydroxy-4.alpha.-(hydroxymethyl)cyclopent-1. alpha.-yl]adenine (II) [62357-70-4]. II had highly significant activity against herpes simplex virus and vaccinia virus, and had a LD50 concn. of 1 .times. 10-5M against P-388 mouse lymphoid leukemia cells in culture. Unlike ara-A, II is completely resistant to deamination by adenosine deaminase. .