Reference

Pharmacological evaluation of YC-93, a new vasodilator, in healthy volunteers

Pharmacological evaluation of YC-93, a new vasodilator, in healthy volunteers. Seki, Takashi; Takenaka, Toichi (Dep. Pharmacol., Kyorin Univ. Sch. Med., Mitaka, Japan). Int. J. Clin. Pharmacol. Biopharm., 15(6), 267-74 (English) 1977. CODEN: IJCBDX. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) On i.v. injection of YC 93 (I) [54527-84-3] in healthy male volunteers, dermal blood flows at the forehead and cheek were increased with doses of 2.5-20 .mu.g/kg and a slight hypotension and tachycardia were obsd. with doses of 10 and 20 .mu.g/kg. Mean half-life of plasma I was 64 mins. On oral I administration, arterial blood pressure and heart rate remained unchanged in doses up to 20 mg. With 40 mg, I caused a slight hypotension and tachycardia. Pharmacokinetic anal. revealed that YC-93 was rapidly absorbed and mean half-life was 81 mins. The systemic availability of I was not influenced by the body position. Following repeated oral administration of I no accumulation of I was obsd. Side-effects possibly produced by I were headache and facial flushing. Thus, I is an effective vasodilator and is well tolerated in single and repeated doses in man.

Absorption, excretion and metabolism of a new dihydropyridine diester cerebral vasodilator in rats and dogs

Absorption, excretion and metabolism of a new dihydropyridine diester cerebral vasodilator in rats and dogs. 59875-61-5 are also occured in this study. Higuchi, S.; Sasaki, H.; Shiobara, Y.; Sado, T. (Cent. Res. Lab., Yamanouchi Pharm. Co. Ltd., Tokyo, Japan). Xenobiotica, 7(8), 469-79 (English) 1977. CODEN: XENOBH. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) The plasma concn. of orally administered, 14C-labeled dihydropyridine diester (I) [54527-84-3] reached a max. at 0.5-1 h in rats and dogs and decreased with a half-life of .apprx.3.5 h. The level of radioactivity in rats was high in the liver, kidney, and lung after oral or i.v. administration of I. In both species, the 48-h feces and urine contained 66-72 and 23-9% of the administered radioactivity resp. Eight metabolites of I were identified in the urine of dogs and rats. .