Reference

Comparative responses of the carotid and vertebral arterial systems of rhesus monkeys to betahistine

Comparative responses of the carotid and vertebral arterial systems of rhesus monkeys to betahistine. Tomita, M.; Gotoh, F.; Sato, T.; Amano, T.; Tanahashi, N.; Tanaka, K.; Yamamoto, M. (Sch. Med., Keio Univ., Keio, Japan). Stroke, 9(4), 382-7 (English) 1978. CODEN: SJCCA7. ISSN: 0039-2499. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Following i.v. administration of betahistine mesylate (I) [54856-23-4], the mean transit times of blood through the carotid and vertebral arteries were equally shortened by 10%, despite a 20% decrease in the mean arterial blood pressure. The cerebral tissue and cerebellar tissue blood flow was increased by I 70.4-81.4 and 73.2-84.0 mL/100g/min, resp. Since histamine has been reported to produce a decrease in cardiac output, the increase in cerebral blood flow confirmed that I is a selective cerebral vasodilating agent. However, by comparing the hemodynamic data for the 2 cerebral arterial systems, the responses of the carotid and vertebral arterial systems to the vasodilating action of I were essentially the same.

Improved determination of betahistine mesylate

Improved determination of betahistine mesylate.Some chemicals with cas registry numbers like 54856-23-4 and 7664-93-9 are also used. Nishide, Shigenori; Mikura, Tamiyuki; Yamada, Terukatsu; Toshima, Yoichi; Nakano, Saburo (Dep. Qual. Manag., Ohta Pharm. Co., Ltd., Saitama 330, Japan). Yakugaku Zasshi, 103(11), 1180-4 (Japanese) 1983. CODEN: YKKZAJ. ISSN: 0031-6903. DOCUMENT TYPE: Journal CA Section: 64 (Pharmaceutical Analysis) An improved method for the detn. of betahistine mesylate (I) [54856-23-4] in tablets was developed by the use of UV spectrophotometry at 260 nm. The detn. of in aq. solns. were affected by pH and temp. The measurement of the mesylate in 0.1 N sulfuric acid instead of water produced more accurate results. .