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CAS No.: | 56-49-5 |
---|---|
Name: | 3-METHYLCHOLANTHRENE |
Article Data: | 23 |
Molecular Structure: | |
Formula: | C21H16 |
Molecular Weight: | 268.358 |
Synonyms: | Cholanthrene,3-methyl- (8CI); 20-MC; 20-Methylcholanthrene; 3-MC; 3-Methylcholanthrene; MCA;Methylcholanthrene; NSC 21970 |
EINECS: | 200-276-4 |
Density: | 1.223 g/cm3 |
Melting Point: | 178-180ºC |
Boiling Point: | 280 ºC 80 mm Hg(lit.) |
Flash Point: | -5ºC |
Solubility: |
Stability
Toxicology
|
Appearance: | yellow crystalline solid |
Hazard Symbols: | Powerful carcinogen. |
Risk Codes: | 45-36-20/21/22-11 |
Safety: | Suspected carcinogen with experimental carcinogenic, neoplastigenic, and tumorigenic data. Poison by intravenous and intraperitoneal routes. Experimental teratogenic and reproductive effects. Human mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes. |
PSA: | 0.00000 |
LogP: | 5.55320 |
6-acetoxy-3-methylcholanthrene
methylcholanthrene
Conditions | Yield |
---|---|
With hydrogen iodide; hypophosphorous acid In propionic acid for 0.166667h; Heating; | 93% |
3ξ-(2-amino-phenyl)-2-(8-methyl-acenaphthen-3-yl)-acrylic acid
methylcholanthrene
Conditions | Yield |
---|---|
With 1,4-dioxane; sulfuric acid; isopentyl nitrite Reagens 4: Aethanol; anschliessendes Erwaermen mit Kupfer-Pulver und danach Erhitzen mit basischem Kupfer(II)-acetat unter vermindertem Druck; |
Conditions | Yield |
---|---|
at 320 - 340℃; Behandlung des Reaktionsprodukts mit Selen bei 320-340grad; |
3-methyl-2,2a,3,4-tetrahydro-1H-benz[j]aceanthrylen-5-one
methylcholanthrene
Conditions | Yield |
---|---|
With hydrogenchloride; amalgamated zinc Erhitzen des Reaktionsprodukts mit Platin/Kohle auf 280grad; |
Conditions | Yield |
---|---|
at 320 - 340℃; Behandlung des Reaktionsprodukts mit Selen bei 320-340grad; |
3-methyl-1,2,2a,3,4,5-hexahydro-benz[j]aceanthrylene
methylcholanthrene
Conditions | Yield |
---|---|
With selenium at 320 - 340℃; |
(7-methyl-indan-4-yl)-[1]naphthyl ketone
methylcholanthrene
Conditions | Yield |
---|---|
at 405 - 410℃; |
(4-methoxy-[1]naphthyl)-(7-methyl-indan-4-yl)-ketone
methylcholanthrene
Conditions | Yield |
---|---|
at 400℃; |
A
methylcholanthrene
B
1,3-dimethyl-cholanthrene
Conditions | Yield |
---|---|
at 405 - 410℃; |
(4-chloro-[1]naphthyl)-(7-methyl-indan-4-yl)-ketone
A
methylcholanthrene
B
11-chloro-3-methyl-cholanthrene
Conditions | Yield |
---|---|
at 410℃; |
1. | otr-hmn:lng 500 μg/L/2W | GANNA2 Gann. Japanese Journal of Cancer Research. 74 (1983),615. | ||
2. | sce-hmn:fbr 1 mmol/L | MUREAV Mutation Research. 117 (1983),47. | ||
3. | orl-rat TDLo:600 mg/kg (MGN):CAR,TER | CNREA8 Cancer Research. 12 (1952),296. | ||
4. | orl-rat TDLo:600 mg/kg (female 60D pre):CAR | CNREA8 Cancer Research. 12 (1952),296. | ||
5. | orl-rat TDLo:600 mg/kg (multi) :CAR | CNREA8 Cancer Research. 12 (1952),296. | ||
6. | orl-mus TDLo:21 mg/kg (15-17D post):CAR,TER | TXAPA9 Toxicology and Applied Pharmacology. 72 (1984),427. | ||
7. | skn-mus TDLo:120 mg/kg (MGN):CAR,TER | BEXBAN Bulletin of Experimental Biology and Medicine. Translation of BEBMAE. 71 (1971),677. | ||
8. | ipr-mus TDLo:5 mg/kg (17D post):CAR,TER | CRNGDP Carcinogenesis. 6 (1985),1389. | ||
9. | ipr-mus LDLo:100 mg/kg | TXAPA9 Toxicology and Applied Pharmacology. 23 (1972),288. | ||
10. | irn-frg LDLo:9 mg/kg | CNREA8 Cancer Research. 24 (1964),1969. |
HANDLING and STORAGE about 3-METHYLCHOLANTHRENE:
Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Minimize dust generation and accumulation. Do not get on skin and clothing. Do not ingest or inhale. Use with adequate ventilation. Do not breathe dust.
Storage:
Store in a tightly closed container. Store in a cool, dry,well-ventilated area away from incompatible substances.storage temp:2-8°C