Detail of "56863-02-6"

Reference

Final report on the safety assessment of cocamide DEA, lauramide DEA, linoleamide DEA, and oleamide DEA

Final report on the safety assessment of cocamide DEA, lauramide DEA, linoleamide DEA, and oleamide DEA. (Cosmetic, Toiletry and Fragrance Assoc., Washington, DC, USA). J. Am. Coll. Toxicol., 5(5), 415-54 (English) 1986. CODEN: JACTDZ. ISSN: 0730-0913. DOCUMENT TYPE: Journal CA Section: 62 (Essential Oils and Cosmetics) Section cross-reference(s): 63 The fatty acid diethanolamides, lauramide DEA [120-40-1], linoleamide DEA [56863-02-6], oleamide DEA [93-83-4], and cocoamide DEA, used in cosmetics and pharmaceuticals, were slightly toxic to nontoxic to rats in formulations and inert vehicles via acute oral administration. Lauramide DEA was not a subchronic oral toxin in rats or dogs; cocamide DEA, lauramide DEA, and linoleamide DEA were mild to moderate eye irritants and mild to severe skin irritants. Undild. oleamide DEA was not an eye irritant and was a moderate skin irritant in single and cumulative applications. Lauramide DEA did not demonstrate mutagenic activity in 3 different Ames-type assays. No data are available on the mutagenic or carcinogenic activity of cocamide DEA, linoleamide DEA, and oleamide DEA. Clin. information on these ingredients was confined to cocamide, lauramide, and linoleamide DEA. Generally, these products were mild skin irritants but not sensitizers or photosensitizers.