Detail of "578-66-5"

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8-Quinolinamine derivatives: 8-Quinolinamine derivatives. Chen, Eugene H.; Saggiamo, Andrew J.; Nodiff, Edward A. (USA ). U. S. Pat. Appl. US 774165 3 Mar 1977,80 pp. Avail. NTIS. (English). (United States of America). CODEN: XAXXAV. APPLICATION: US 77-774165 3 Mar 1977. DOCUMENT TYPE: Patent CA Section: 27 (Heterocyclic Compounds (One Hetero Atom)) About 28 8-substituted aminoquinolines were prepd. by reaction of the resp.Except for chemicals metioned above, 78-85-3 is also used. 8-aminoquinoline with a substituted alkyl halide in the presence of an amine with a b. 80-90°. E.g., quinocide monophosphate was obtained in 63% yield by reaction of 6-methoxy-8-(4-phthalimidopentylamino)quinoline hydrochloride (I) with N2H4.H2O, followed by H3PO4. 78-85-3 are also occured in this study. I was prepd. in 39% yield by reaction of 1-iodo-4-phthalimidopentane (II) with 8-amino-6-methoxyquinoline. II was prepd. from MeCOCH2CH2CH2OH via MeCH(NH2)(CH2)3OH, 4-phthalimido-1-pentanol, and 1-chloro-4-phthalimidopentane. ..

Comparative mutagenesis of quinolines: Comparative mutagenesis of quinolines. Epler, J. L.; Winton, W.; Ho, Ti; Larimer, Frank W.; Rao, T. K.; Hardigree, Alice A. (Biol. Div., Oak Ridge Natl. Lab., Oak Ridge, Tenn., USA). Mutat. Res., 39(3-4), 285-96 (English) 1977. CODEN: MUREAV. DOCUMENT TYPE: Journal CA Section: 3 (Biochemical Interactions) Quinoline (I) [91-22-5], 8-hydroxyquinoline [148-24-3], 8-nitroquinoline [607-35-2], and 8-aminoquinoline [578-66-5] were mutagenic in Salmonella when assayed by histidine reversion. Metabolic activation was required for the max. effect. Frameshift mutagenesis appeared to be the mechanism with 8-nitro- and 8-aminoquinoline. I and 8-hydroxyquinoline effected only the sensitive TA100 (missense, R factor) strain. 8-Amino- and 8-hydroxyqinolines induced chromatid aberrations in human leukocytes. 8-Nitroquinoline had no effect at the concns. tested. 8-Aminoquinoline was not effective in yeast when assayed by forward mutation, gene conversion, or mitotic recombination; fluctuattion tests showed a weak effect. 8-Aminoquinoline was not an effective mutagen in Drosophila when assayed for sex-linked recessive lethals by an adult feeding method.