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CAS No.: | 57848-46-1 |
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Name: | 4-Bromo-2-fluorobenzaldehyde |
Article Data: | 10 |
Molecular Structure: | |
Formula: | C7H4BrFO |
Molecular Weight: | 203.011 |
Synonyms: | 4-bromo-2-fluoro-benzaldehyde;2-fluoro-4-bromobenzaldehyde;2-bromo-4-fluorobenzaldehyde; |
EINECS: | 298-056-6 |
Density: | 1.67 g/cm3 |
Melting Point: | 59-64 °C |
Boiling Point: | 241.4 °C at 760 mmHg |
Flash Point: | 99.8 °C |
Solubility: | Insoluble in water |
Appearance: | light yellow to beige crystalline crystals |
Hazard Symbols: | Xi |
Risk Codes: | 36/37/38 |
Safety: | 37/39-26-36 |
PSA: | 17.07000 |
LogP: | 2.40070 |
2,5-dibromofluorobenzene
N,N-dimethyl-formamide
4-bromo-2-fluorobenzaldehyde
Conditions | Yield |
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Stage #1: 2,5-dibromofluorobenzene With tri-n-butyllithium magnesate complex In tetrahydrofuran; toluene at 0℃; for 1h; Stage #2: N,N-dimethyl-formamide In toluene at 0℃; for 0.5h; Stage #3: With citric acid at 20℃; | 92% |
Stage #1: 2,5-dibromofluorobenzene With n-butyllithium In diethyl ether at -100℃; for 0.75h; Stage #2: N,N-dimethyl-formamide In diethyl ether at -90℃; for 0.25h; Stage #3: With sulfuric acid In diethyl ether; water at -50℃; | 86% |
Stage #1: 2,5-dibromofluorobenzene With isopropylmagnesium bromide In tetrahydrofuran at 0 - 5℃; for 1.5h; Stage #2: N,N-dimethyl-formamide In tetrahydrofuran; toluene at 0 - 5℃; for 4h; Stage #3: With acetic acid In tetrahydrofuran; water; toluene at 0 - 10℃; |
4-bromo-2-fluorobenzyl alcohol
4-bromo-2-fluorobenzaldehyde
Conditions | Yield |
---|---|
With tert.-butylhydroperoxide; tetrabutylammomium bromide In decane; benzene at 40℃; for 24h; Inert atmosphere; Sealed tube; chemoselective reaction; | 87% |
2,5-dibromofluorobenzene
butyl magnesium bromide
4-bromo-2-fluorobenzaldehyde
Conditions | Yield |
---|---|
With n-butyllithium; acetic acid In tetrahydrofuran; hexane; N,N-dimethyl-formamide; toluene | 82% |
4-bromo-3-fluorobenzyl alcohol
4-bromo-2-fluorobenzaldehyde
Conditions | Yield |
---|---|
With sodium acetate; pyridinium chlorochromate In dichloromethane at 20℃; for 2h; | 63% |
With sodium acetate; pyridinium chlorochromate In dichloromethane at 20℃; for 2h; light protection; | 63% |
N-(4-bromo-2-fluoro-benzyl)-acetamide
4-bromo-2-fluorobenzaldehyde
Conditions | Yield |
---|---|
With N-Bromosuccinimide In chloroform at 20℃; for 18h; | 51% |
Conditions | Yield |
---|---|
With acetic anhydride In ethanol; water; acetic acid |
4-bromo-2-fluorobenzaldehyde oxime
4-bromo-2-fluorobenzaldehyde
Conditions | Yield |
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With acetic anhydride In ethanol at 140℃; |
3-fluorobromobenzene
N,N-dimethyl-formamide
4-bromo-2-fluorobenzaldehyde
Conditions | Yield |
---|---|
Stage #1: 3-fluorobromobenzene With lithium diisopropyl amide In tetrahydrofuran at -78℃; Stage #2: N,N-dimethyl-formamide In tetrahydrofuran |
4-bromo-3-fluorobenzoic acid
4-bromo-2-fluorobenzaldehyde
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: sodium tetrahydroborate; boron trifluoride diethyl etherate / tetrahydrofuran / 2 h / 20 °C 2: sodium acetate; pyridinium chlorochromate / dichloromethane / 2 h / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1: sodium tetrahydroborate; boron trifluoride diethyl etherate / tetrahydrofuran / 2 h / 20 °C / Cooling with ice 2: sodium acetate; pyridinium chlorochromate / dichloromethane / 2 h / 20 °C / light protection View Scheme |
4-bromo-3-fluorotoluene
4-bromo-2-fluorobenzaldehyde
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: pyridine; water; potassium permanganate / 3 h / 90 °C 1.3: pH 2 2.1: sodium tetrahydroborate; boron trifluoride diethyl etherate / tetrahydrofuran / 2 h / 20 °C 3.1: sodium acetate; pyridinium chlorochromate / dichloromethane / 2 h / 20 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: potassium permanganate / pyridine; water / 3 h / 90 °C 1.2: pH 2 1.3: pH 2 2.1: sodium tetrahydroborate; boron trifluoride diethyl etherate / tetrahydrofuran / 2 h / 20 °C / Cooling with ice 3.1: sodium acetate; pyridinium chlorochromate / dichloromethane / 2 h / 20 °C / light protection View Scheme |
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Structure of 4-Bromo-2-Fluorobenzaldehyde (CAS NO.57848-46-1):
IUPAC Name: 4-bromo-2-fluorobenzaldehyde
Empirical Formula: C7H4BrFO
Molecular Weight: 203.0085
Index of Refraction: 1.584
Molar Refractivity: 40.68 cm3
Molar Volume: 121.4 cm3
Polarizability: 16.13×10-24cm3
Surface Tension: 42.3 dyne/cm
Density: 1.67 g/cm3
Flash Point: 99.8 °C
Enthalpy of Vaporization: 47.84 kJ/mol
Melting Point: 59-64 °C
Boiling Point: 241.4 °C at 760 mmHg
Vapour Pressure: 0.036 mmHg at 25°C
Water Solubility: INSOLUBLE
Sensitive: Air Sensitive
Physical Appearance: light yellow to beige crystal
Product Categories: Fluorin-contained benzaldehyde series;FINE Chemical & INTERMEDIATES;Fluorobenzene;Aromatic Aldehydes & Derivatives (substituted);Benzene series;Benzaldehyde;Miscellaneous;Adehydes, Acetals & Ketones;Bromine Compounds;Fluorine Compounds;Benzaldehyde (Building Blocks for Liquid Crystals);Building Blocks for Liquid Crystals;Functional Materials;Aldehydes;C7;Carbonyl Compounds
4-Bromo-2-Fluorobenzaldehyde (CAS NO.57848-46-1) is used as intermediates in synthesis pharmaceutical and pesticide .
Hazard Codes: Xi
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 37/39-26-36
S37/39:Wear suitable gloves and eye/face protection.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
Hazard Note: Irritant
HazardClass: IRRITANT, AIR SENSITIVE
4-Bromo-2-Fluorobenzaldehyde , its cas register number is 57848-46-1. It also can be called Benzaldehyde, 4-bromo-2-fluoro- ; 2-Fluoro-4-bromobenzaldehyde ; 4-Bromo-2-Fluorobenzaldehyde2-Fluoro-4-Bromobenzaldehyde .