Detail of "58-54-8"

Reference

Ethacrynic acid administration following renal denervation in unanesthetized dogs

Ethacrynic acid administration following renal denervation in unanesthetized dogs. Kabakchieva, E.; Gurchev, R.; Tsachev, K.; Toneva, Z.; Nachev, N. (Med.-Biol. Inst., Sofia, Bulg.). Med.-Biol. Probl., 12, 65-70 (Bulgarian) 1984. CODEN: MBLPA3. ISSN: 0323-9802. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Following the administration of ethacrynic acid [58-54-8] to unanesthetized dogs with exteriorized ureters and renal denervation, the vol. of urine excreted by the kidney is increased in comparison to the intact kidney. The excretion of Cl-, Cu2+, and Mg2+ is also increased. The differences in excretion pattern in these expts. is most probably due to the reduced reabsorption of electrolytes in the proximal tubules, and to the enhanced glomerular filtration subsequent to renal denervation.

Rapid, substrate-specific, and dose-dependent deactivation of liver cytosolic glutathione S-transferases in vivo by 1,1-dichloroethylene

Rapid, substrate-specific, and dose-dependent deactivation of liver cytosolic glutathione S-transferases in vivo by 1,1-dichloroethylene. Moslen, Mary Treinen; Reynolds, Edward S. (Dep. Pathol., Univ. Texas Med. Branch, Galveston, TX 77550, USA). Res. Commun. Chem. Pathol. Pharmacol., 47(1), 59-72 (English) 1985. CODEN: RCOCB8. ISSN: 0034-5164. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) The administration of 200 mg 1,1-dichloroethylene (DCE) [75-35-4]/kg to fasted rats rapidly decreased liver cytosolic glutathione S-transferase [50812-37-8] activities by 50% within 1 h. This early decrease was not assocd. with increased serum activities of this sol. enzyme and is considered due to the enzyme deactivation. The early decrease in enzyme activities was concomitant with a 75% depletion of cytosolic GSH [70-18-8] and preceded changes in cytochrome P 450 [9035-51-2] and the onset of liver cytotoxicity, both of which occurred abruptly between 2 and 3 h. Substantial changes in glutathione S-transferase activities at 4 h were produced only by severely hepatotoxic doses of DCE. The early decrease in hepatic glutathione S-transferase activities was selective for the substrates dichloronitrobenzene [27900-75-0], chlorodinitrobenzene [25567-67-3], and 1,2-epoxy-3-(p-nitrophenoxy)propane [5255-75-4] with apparent sparing of activity towards ethacrynic acid [58-54-8]. The rapid, selective, and dose-dependent deactivation of the hepatic glutathione S-transferase isoenzymes could be relevant to the catastrophic hepatotoxicity of DCE.