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Detail of "58-94-6"

  • CAS Number:
  • 58-94-6
  • Name:

  • 2H-1,2,4-Benzothiadiazine-7-sulfonamide,6-chloro-, 1,1-dioxide

  • Superlist Name:
  • Chlorothiazide
  • Molecular Structure:
  • Formula:
  • C7H6ClN3O4S2
  • Molecular Weight:
  • 295.73
  • Synonyms:
  • 6-Chloro-2H-1,2,4-benzothiadiazine-7-sulfonamide1,1-dioxide;6-Chloro-7-sulfamoyl-2H-1,2,4-benzothiadiazine 1,1-dioxide;6-Chloro-7-sulfamyl-1,2,4-benzothiadiazine 1,1-dioxide;Alurene;Chlorosal;Chlorothiazid;Chlorothiazide;Chlorthiazide;Chlorurit;Chlotride;Clotride;Diuresal;Diuril;Diuril Boluses;Diurilix;Diurite;Diutrid;Flumen;Minzil;NSC 25693;Neo-Dema;Salisan;Salunil;Saluretil;Saluric;Thiazide;Urinex;Warduzide;Yadalan;
  • EINECS:
  • 200-404-9
  • Density:
  • 2.04g/cm3
  • Melting Point:
  • 342-343 ºC
  • Boiling Point:
  • 608.8°Cat760mmHg
  • Flash Point:
  • 322°C
  • Solubility:
  • Water Solubility :<0.1 g/100 mL at 19.5 ºC
  • Appearance:
  • white crystalline powder
  • Hazard Symbols:
  • Risk Codes:
  • 42/43-20/21/22
  • Safety:
  • 36 Details
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CAS No.58-94-6 ChlorothiazideCompetitive Product

Chlorothiazide

Supplier:AUSHUN PHARMACEUTICAL TECHNOLOGY CO,.LTD [ China (Mainland)]

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CAS No.58-94-6 Chlorothiazide

Chlorothiazide

Supplier:Anhui Charm Imp.&Exp.Co., Ltd [ China (Mainland)]

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CAS No.58-94-6 Chlorothiazide

Chlorothiazide

Supplier:TCS INDUSTRY LIMITED [ China (Mainland)]

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CAS No.58-94-6 Chlorothiazide

Assay:98%

Supplier:Hangzhou Dayangchem Co., Ltd. [ China (Mainland)]

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CAS No.58-94-6 Chlorothiazide

Chlorothiazide

Supplier:Spectrum China Ltd. [ China (Mainland)]

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CAS No.58-94-6 Chlorothiazide

Assay:BP/USP

Supplier:Changzhou Highassay Chemical Co., Ltd [ China (Mainland)]

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CAS No.58-94-6 Chlorothiazide

Supplier:SHIJIAZHAUNG KUNLI CHEMICAL CO.LTD., [ China (Mainland)]

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CAS No.58-94-6 Chlorothiazide

Chemical Name 6-chloro-7-sulfamyl-1,2,4-benzothiadiazine 1,1-dioxide CAS# Molecular Formula Molecular Weight 58-94-6 C7H6ClN3O4S2 295.7 Packing 25kg/drum Capacity 2MT/month Storage Store in a tightly sealed container away from heat and direc

Supplier:Changzhou Comwin Fine Chemicals Co., Ltd [ China (Mainland)]

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CAS No.58-94-6 Chlorothiazide

[ Molecular formula ] C7H6ClN3O4S2 [ Molecular weight ] 295.72 [ Packing specification ] 5Kg / tin, 25Kg / drum [ Storage ] Store in an airtight container, protected from light. [ Executive standard ] USP29, BP2005 [ Main index ] Appearance

Supplier:Suzhou Leader Chemical Co., Ltd. [ China (Mainland)]

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CAS No.58-94-6 Chlorothiazide

Chlorothiazide

Supplier:Jai Radhe Sales [ India]

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CAS No.58-94-6 Chlorothiazide

Chlorothiazide is a diuretic and antihypertensive. (IC50=3.8 mM)

Supplier:Selleck Chemicals [ United States]

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CAS No.58-94-6 Chlorothiazide

Chlorothiazide

Supplier:Manus Aktteva Biopharma LLP [ India]

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CAS No.58-94-6 Chlorothiazide

Chlorothiazide

Supplier:Agno Pharma [ United States]

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CAS No.58-94-6 Chlorothiazide

Supplier:Suzhou Lixin Pharmaceutical Co., Ltd. [ China (Mainland)]

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CAS No.58-94-6 Chlorothiazide

Supplier:CTX Life Sciences Pvt. Ltd. [ India]

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CAS No.58-94-6 Chlorothiazide

Supplier:Hubei Hengluyuang Technology Co.,Ltd [ China (Mainland)]

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CAS No.58-94-6 Chlorothiazide

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CAS No.58-94-6 Chlorothiazide

Supplier:CTX Life Sciences Pvt Lilimted [ India]

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CAS No.58-94-6 Chlorothiazide

Supplier:Concept Group of Companies [ India]

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CAS No.58-94-6 Chlorothiazide

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CAS No.58-94-6 Chlorothiazide

Supplier:Suzhou Leader Imp.& Exp. Co., Ltd. [ China (Mainland)]

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CAS No.58-94-6 Chlorothiazide

Supplier:ADVANCED TECH. & IND. CO., LTD. [ Hong Kong]

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Reference

Determination of diuretic compounds using potassium hexacyanoferrate(III) or N-chlorosuccinimide
Determination of diuretic compounds using potassium hexacyanoferrate(III) or N-chlorosuccinimide. Shukla, I. C.; Ahmad, S.; Singh, D.; Srivastava, M. K. (Dep. Chem., Univ. Allahabad, Allahabad 211 002, India). Indian J. Pharm. Sci., 45(6), 249-50 (English) 1983. CODEN: IJSIDW. ISSN: 0250-474X. DOCUMENT TYPE: Journal CA Section: 64 (Pharmaceutical Analysis) Diuretics were detd. in tablets and injections by dissolving in concd. HCl (furosemide [54-31-9] and ethacrynic acid [58-54-8]) or 4N NaOH and then dilg. with H2O (hydrochlorothiazide [58-93-5], chlorothiazide [58-94-6], and polythiazide [346-18-9]) and then mixing with 0.1N K hexacyanoferrate (III) [13746-66-2], 8M H2SO4, and 3% ZnSO4 and incubating at 50° for 35 min. Alternatively, the diuretic solns. were mixed with 0.01N N-chlorosuccinimide [128-09-6] and 6M HCl, and allowed to stand at room temp. for 20 min. The excess reagent was detd. iodometrically (10% KI) by titrating with 0.1N Na2S2O3 with starch indicator. The error was ±1% and the std. deviations were less than with the British Pharmacopeia method. Tablet excipients did not interfere, but phenols and thioureas did.
Physicochemical model for dose-dependent drug absorption
Physicochemical model for dose-dependent drug absorption. Dressman, J. B.; Fleisher, D.; Amidon, G. L. (Res. Lab., Merck Sharp and Dohme, Lawrence, KS 66044, USA). J. Pharm. Sci., 73(9), 1274-9 (English) 1984. CODEN: JPMSAE. ISSN: 0022-3549. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 63 A two-tank perfect-mixing tank model was used to simulate GI absorption. The effect of drug parameters [pKa, (soly. const.), soly., and intrinsic wall permeability] and system parameters (pH profile, vol. of intestinal contents, and intestinal flow rate) on drug absorption were studied by numerical data simulation. When the dose did not exceed the soly. of the drug in the intestinal lumen, the fraction absorbed depended on the transit rate relative to the absorption rate and the pKa relative to the pH profile, but was independent of drug dose. Satn. of one or both tanks led to dose-dependent absorption. The model was used to simulate absorption of chlorothiazide [58-94-6]. Good agreement between simulated and exptl. data led to the conclusion that the phys. characteristics of chlorothiazide, rather than a saturable transport mechanism at the intestinal wall, may be responsible for the dose-dependent absorption obsd. for this drug. The model was also used to simulate hydrochlorothiazide [58-93-5] absorption. By applying the same system parameters used for chlorothiazide, the model simulation correctly predicted the dose proportionality of hydrochlorothiazide absorption. The lack of dose dependency in this case may be attributed to the higher soly. and pKa of hydrochlorothiazide compared with chlorothiazide.
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