Detail of "582-24-1"

Reference

Thermoplastic foam mixtures

Thermoplastic foam mixtures. Niznik, George Elliot (General Electric Co., USA). Ger. Offen. DE 2637736 3 Mar 1977, 30 pp. (German). (Germany). CODEN: GWXXBX. CLASS: IC: C08J009-06. PRIORITY: US 75-608451 28 Aug 1975. DOCUMENT TYPE: Patent CA Section: 36 (Plastics Manufacture and Processing) Section cross-reference(s): 28 3,6-Dihydro-5-phenyl-1,3,4-oxadiazin-2-one (I, R = H) [62501-39-7] and I (R = Ph) [19836-49-8] were used as blowing agents for polycarbonates, polyolefins, polyamides, and other thermoplastics. The blowing agents did not degrade the polymers during extrusion and foaming. Thus, MeCOPh [98-86-2] was brominated and converted to HOCH2COPh [582-24-1] which was treated with H2NNHCO2Me [6294-89-9] and cyclized to prep. I (R = H). A polycarbonate had intrinsic viscosity 0. 9003-53-6 and 63394-03-6 are also in the experiment.54 dL/g initially and 0.53 dL/g after mixing with 0.6% I (R = H) and extrusion at 305.degree. to give foam with d. 0.86. .

Isolation and identification of some metabolites of phenyramidol (Cabral) from human urine

Isolation and identification of some metabolites of phenyramidol (Cabral) from human urine. Goenechea, S.; Eckhardt, G.; Goebel, K. J. (Inst. 553-69-5 are also occured in this study. Gerichtl. Med., Univ. Bonn, Bonn, Ger.). J. Clin. Chem. Clin. Biochem., 15(9), 489-98 (German) 1977. CODEN: JCCBDT. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) The biol. transformation of phenyramidol (I) [553-69-5], some of which was also excreted unchanged, occurred by 3 main degradative pathways: hydroxylation of the pyridine ring in position 3 and 5, cleavage of the ethanolamine chain with the formation of 2-aminopyridine [504-29-0] and presumably mandelic aldehyde, and conjugaton with glucuronic acid. Secondary reactions resulted in the prodn. of benzoyl carbinol [582-24-1], benzoic acid [65-85-0], mandelic acid [90-64-2], and the glucuronides of several metabolites which were also found as free, unconjugated compds. A further, unusual reaction is the dimerization of a hydroxy metabolite of I with the formation of a dipyridyl deriv., which is excreted partly as the free compd., but mainly as the glucuronide. The occurrence of 2-(N-benzylamino)pyridine [6935-27-9] in the urine could not be explained. Four further excretory products were not identified; 2 of them were extd. at an alk. 553-69-5 is also in the experiment. pH, whereas the other 2 were extd. under neutral conditions. They could be detected both as free compds., and after hydrolysis with HCl or alkali, but not after treatment with b-glucuronidase. ..