Detail of "58994-96-0"

Reference

Effects of combination chemotherapy of MCNU with various anticancer agents

Effects of combination chemotherapy of MCNU with various anticancer agents. Machida, Satoshi; Ito, Yoshinori; Hoshino, Akira (Dep. Med., Anjo Kosei Hosp., Japan). Gan to Kagaku Ryoho, 12(2), 298-302 (Japanese) 1985. CODEN: GTKRDX. ISSN: 0385-0684. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The combined administration of MCNU [58994-96-0] and 5-fluorouracil [51-21-8] w effective against leukemic L-1210 cells, whereas MCNU and cyclophosphamide [50-18-0] were synergistic against L-1210 cells and leukemic P-388 cells. Efficacies of MCNU with 10 other drugs are shown.

Time-schedule dependency of the inhibiting activity of various anticancer drugs in the clonogenic assay

Time-schedule dependency of the inhibiting activity of various anticancer drugs in the clonogenic assay. Matsushima, Yuka; Kanzawa, Fumihiko; Hoshi, Akio; Shimizu, Eiji; Nomori, Hiroaki; Sasaki, Yasutsuna; Saijo, Nagahiro (Pharmacol. Div., Natl. Cancer Cent. Res. Inst., Tokyo 104, Japan). Cancer Chemother. Pharmacol., 14(2), 104-7 (English) 1985. CODEN: CCPHDZ. ISSN: 0344-5704. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) To analyze the discrepancy between the in vitro response in the clonogenic assay and the clin. response, the time-schedule dependencies of various anticancer drugs were detd. by comparing the inhibiting effect against colony formation by PC-7 cells treated with the drugs for 1 h with that of those treated for 24 h. According to their schedule dependency the drugs can be divided into a schedule-dependent drug group (5-fluorouracil [51-21-8], methotrexate [59-05-2], bleomycin [11056-06-7], pepleomycin [68247-85-8], etoposide [33419-42-0], cisplatin [15663-27-1], teniposide [29767-20-2], vindesine [53643-48-4], and vinblastine [865-21-4]) and a non-schedule-dependent drug group (adriamycin [23214-92-8], actinomycin D [50-76-0], ranomustine [58994-96-0], mitomycin C [50-07-7], aclacinomycin [66676-88-8], daunomycin [20830-81-3], nimustine [42471-28-3], melphalan [148-82-3], and KW 2083 [70343-57-6]). In the clonogenic assay, the 1-h exposure schedule is appropriate for predicting clin. response for the non-schedule-dependent drugs. However, the effect of the schedule-dependent drugs was underestd. in the same conditions. Therefore, it is necessary to test these drugs in the assay by 24-h exposure for a more accurate assessment of their antitumor activity.