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CAS No.: | 59-33-6 |
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Name: | PYRILAMINE MALEATE |
Molecular Structure: | |
Formula: | C17H23N3O•C4H4O4 |
Molecular Weight: | 401.462 |
Synonyms: | 1,2-Ethanediamine, N1-[(4-methoxyphenyl)methyl]-N2,N2-dimethyl-N1-2-pyridinyl-, (2Z)-2-butenedioate (1:1);ANTHISAN;histosol;N-(4-Methoxybenzyl)-N',N'-dimethyl-N-(2-pyridinyl)-1,2-ethanediamine (2Z)-2-butenedioate (1:1);N-(4-Methoxybenzyl)-N',N'-dimethyl-N-(pyridin-2-yl)ethane-1,2-diamine (2Z)-but-2-enedioate (1:1);N-(4-methoxybenzyl)-N',N'-dimethyl-N-pyridin-2-ylethane-1,2-diamine (2Z)-but-2-enedioate;N-[(4-Methoxyphenyl)methyl]-N',N'-dimethyl-N-2-pyridinyl-1,2-ethanediamine (2Z)-2-Butenedioate (1:1);N-p-Methoxybenzyl-N',N'-dimethyl-N-a-pyridylethylenediamine Maleate;Thylogen; |
EINECS: | 200-422-7 |
Melting Point: | 101-103 °C |
Boiling Point: | 423.8 °C at 760 mmHg |
Flash Point: | 210.1 °C |
Solubility: | Soluble in water at 100mg/ml |
Appearance: | solid |
Hazard Symbols: | Xn |
Risk Codes: | 22-36/37/38 |
Safety: | 26-36/37 |
PSA: | 103.20000 |
LogP: | 2.37020 |
mepyramine maleate
Conditions | Yield |
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With sodium methylate In methanol; dimethyl sulfoxide for 96h; Heating; | 57% |
mepyramine maleate
Conditions | Yield |
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With CH3COOH In acetic acid byproducts: CH3COOK, H2O, HCN; aq. acetic acid; 20-30 min, 80°C; CO2 bubbled (few h) to remove HCN; ppt. washed (H2O repeatedly; ethanol); dried (vac., over silica gel, room temp., to const. wt.); elem.anal.; | 53% |
mepyramine maleate
iodomepyramine
Conditions | Yield |
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With 3-chloro-benzenecarboperoxoic acid; sodium iodide In acetic acid at 22℃; for 1.5h; | 47% |
mepyramine maleate
Conditions | Yield |
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In acetic acid aq. acetic acid; shaking, reflux (80°C, 1-2 h), ice cooling, pptn.; filtration, washing (CH3COOH(aq.), water), drying (vac., room temp.); elem. anal.; | 40% |
mepyramine maleate
N-(4-hydroxy-3,5-di-iodobenzyl)-N',N'-dimethyl-N-2-pyridinyl-1,2-ethanediamine
Conditions | Yield |
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Multi-step reaction with 2 steps 1: 57 percent / sodium methoxide / methanol; dimethylsulfoxide / 96 h / Heating 2: iodine, potassium iodide, 30percent aq. methylamine / H2O / 1.) 10 deg C, 3 h, 2.) 23 deg C, 10 h View Scheme |
Product Name: Pyrilamine maleate (CAS NO.59-33-6)
Molecular Formula: C21H27N3O5
Molecular Weight: 401.46g/mol
Mol File: 59-33-6.mol
Einecs: 200-422-7
Appearance: White crystals or powder
Melting Point: 100-101ºC
Boiling point: 423.8 °C at 760 mmHg
Storage Temperature: 2-8°C
Flash Point: 210.1 °C
Water Solubility: Appreciable
Stability: Stability Combustible. Incompatible with strong oxidizing agents.
Enthalpy of Vaporization: 67.82 kJ/mol
Vapour Pressure: 2.17E-07 mmHg at 25°C
H-Bond Donor: 2
H-Bond Acceptor: 8
Product Categories: Histamine receptor
Pyrilamine maleate (CAS NO.59-33-6) is used as bulk pharmaceutical (antihistaminic).
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
child | LDLo | oral | 42mg/kg (42mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA GASTROINTESTINAL: NAUSEA OR VOMITING | Lancet. Vol. 2, Pg. 809, 1952. |
guinea pig | LD50 | intravenous | 24400ug/kg (24.4mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 113, Pg. 313, 1958. | |
guinea pig | LD50 | subcutaneous | 44mg/kg (44mg/kg) | Annales Pharmaceutiques Francaises. Vol. 20, Pg. 463, 1962. | |
mouse | LD50 | intraperitoneal | 100mg/kg (100mg/kg) | Planta Medica. Vol. 42, Pg. 75, 1981. | |
mouse | LD50 | intravenous | 23mg/kg (23mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 155, Pg. 47, 1965. | |
mouse | LD50 | oral | 220mg/kg (220mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 155, Pg. 47, 1965. | |
mouse | LD50 | subcutaneous | 141mg/kg (141mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 14, Pg. 940, 1964. | |
rat | LD50 | oral | 513mg/kg (513mg/kg) | Toxicology and Applied Pharmacology. Vol. 1, Pg. 42, 1959. | |
rat | LDLo | subcutaneous | 150mg/kg (150mg/kg) | BEHAVIORAL: TREMOR | Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. Vol. 144, Pg. 887, 1950. |
women | TDLo | oral | 200mg/kg (200mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD CARDIAC: OTHER CHANGES VASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION | JAMA, Journal of the American Medical Association. Vol. 257, Pg. 660, 1987. |
Reported in EPA TSCA Inventory.
A human poison by ingestion. An experimental poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Experimental reproductive effects. Questionable carcinogen with experimental tumorigenic data. Mutation data reported. An antihistamine. When heated to decomposition it emits toxic fumes of NOx.
Safety Information of Pyrilamine maleate (CAS NO.59-33-6):
Hazard Codes: Xn
Risk Statements: 22-36/37/38
22: Harmful if swallowed
36: Irritating to the eyes
37: Irritating to the respiratory system
38: Irritating to the skin
Safety Statements: 26-36/37
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36: Wear suitable protective clothing
37: Wear suitable gloves
Pyrilamine maleate ,its CAS NO. is 59-33-6,the synonyms is Mepyramine maleate ; Mepyramine maleate salt ; 2-[(2-Dimethylaminoethyl)(p-methoxybenzyl)amino]pyridine maleate ; Pyrilamine maleate ; Pyrilamine maleate salt ; Pyranisamine maleate ; n-(P-methoxybenzyl)-n',n'-dimethyl-n-2-pyridylethylenediamine maleate ; n-[4-Methoxy-phenyl]methyl-n',n'-dimethyl-n[2-pyridinyl]-1,2-ethanediamine maleate salt .