Reference

A simple synthesis of 2(3H)-benzoxazolones using phenyl chloroformate

A simple synthesis of 2(3H)-benzoxazolones using phenyl chloroformate. Maleski, Robert J.; Osborne, C. Edward; Cline, Sharon M. (Org. Chem. Div.Some commonly used reagents like 603-85-0 and 99-57-0 are used in this experiment., Tennessee Eastman Co., Kingsport, TN 37662-5231, USA). J. Heterocycl. Chem., 28(8), 1937-9 (English) 1991. CODEN: JHTCAD. ISSN: 0022-152X. DOCUMENT TYPE: Journal CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) 2(3H)-Benzoxazolones I (R1 = R2 = H, R3 = H, Me, OMe; R1 = R3 = H, R2 = Me, NO2; R1 = NO2, R2 = R3 = H; R1 = R3 = H, R2 = CO2Et) were prepd. directly from the corresponding 2-aminophenols and Ph chloroformate in 66-83% yield. The intermediate 2-hydroxyphenylcarbamates are formed easily in aq. alc. solvent and these are converted rapidly to product, without their isolation, using one equiv. of NaOH. The synthesis accommodates a wide variety of substituents, including the easily hydrolyzed Et ester. .

Synthesis of newer N-Mannich bases of benzazoles incorporating 2-(4-aminophenyl) 5 or (6) substituted benzimidazoles as potential antiviral agents

Synthesis of newer N-Mannich bases of benzazoles incorporating 2-(4-aminophenyl) 5 or (6) substituted benzimidazoles as potential antiviral agents. Singh, V. A.; Varma, R. S. (Dep. Chem., Lucknow Univ., Lucknow 226 007, India). Indian Drugs, 23(10), 542-4 (English) 1986. CODEN: INDRBA. ISSN: 0019-462X. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 26 A series of p-(2-(5) or (6) substituted)benzimidazolylphenylaminomethyl benzazoles were synthesized by Mannich reaction of benzoxazolin-2 one [59-49-4] derivs., benzoxazolin-2-thione [2382-96-9] derivs., benzothiazolin-2-thione [149-30-4] derivs., benzimidazole [51-17-2], and 4-nitrophthalimide [89-40-7], with 2-(4-aminophenyl)benzimidazole [2963-77-1] and (5) [39861-21-7] or (6)-chloro-2-(p-aminophenyl)benzimidazole [39861-21-7].In this experiment, several chemicals are used like 89-40-7 and 106085-93-2 The title compds. were evaluated for their antiviral activity against sunnhemp rosette virus and tobacco mosaic virus. .