Detail of "59467-94-6"

Reference

Transdermal delivery of anxiolytics: in vitro skin permeation of midazolam maleate and diazepam

Transdermal delivery of anxiolytics: in vitro skin permeation of midazolam maleate and diazepam. Touitou, Elka (Sch. Pharm., Hebrew Univ., Jerusalem, Israel). Int. J. Pharm., 33(1-3), 37-43 (English) 1986. CODEN: IJPHDE. ISSN: 0378-5173. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 1 The skin permeation of midazolam maleate (I) [59467-94-6] and diazepam (II) [439-14-5] from various solvent systems were investigated. Results were computed using a program designed to manipulate skin permeation data. The permeation rates of I and II may be affected by using aq. mixts. of polar org. solvents. Azone [59227-89-3] (1 and 5%) increased the permeation fluxes of both drugs. In the presence of 5% Azone in a solvent system of propylene glycol [57-55-6]- EtOH [64-17-5]-H2O, the fluxes were increased <43-fold for II and 86-fold for I. The performance of a novel hydrophilic transdermal matrix contg. 50 mg I was tested in vitro. 64-17-5 and 57-55-6 are just another two chemicals used in this study. The steady-state flux obtained was used for a coarse estn. of the feasibility of transdermal administration of I. .

Actions of midazolam in the spinal cord of the cat

Actions of midazolam in the spinal cord of the cat. Leah, J. D.; Malik, R.; Curtis, D. R. (Dep. Pharmacol., John Curtin Sch. Med. Res., Canberra City 2601, Australia). Neuropharmacology, 22(12A), 1349-56 (English) 1983. CODEN: NEPHBW. ISSN: 0028-3908. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Midazolam maleate (I) [59467-94-6], which induces anesthesia in humans at i.v. doses of 0.3 mg/kg, did not anesthetize cats at doses of 20 mg/kg. Nevertheless, i.v. doses as small as 0.3 mg/kg enhanced spinal primary afferent depolarization and presynaptic inhibition of spinal monosynaptic reflexes, and both i.v. and microelectrophoretic administration of midazolam enhanced the inhibitory effect of GABA [56-12-2] on spinal neurons and the depolarization of Ia afferent terminations by GABA and piperidine-4-sulfonate [72450-62-5]. Some degree of specificity was demonstrated for the inhibitory effect of GABA in relation to that of glycine [56-40-6] and noradrenaline bitartrate [51-40-1], and the enhancement by midazolam of inhibition by GABA was blocked by R015-1788, which alone was inactive. Although these results are consistent with proposals that depressant benzodiazepines enhance the effectiveness of GABA as a central transmitter, such an effect alone may not fully account for the anesthesia produced by midazolam in humans.