Reference

Dicarboxylic acids and esters containing a heterocyclic group

Dicarboxylic acids and esters containing a heterocyclic group. Habermeier, Juergen (Ciba-Geigy A.-G., Switz.). Ger. Offen. DE 2720836 1 Dec 1977, 36 pp. (German). (Germany). CODEN: GWXXBX. CLASS: IC: C07D235-26. PRIORITY: CH 76-5932 12 May 1976. DOCUMENT TYPE: Patent CA Section: 35 (Synthetic High Polymers) Section cross-reference(s): 28 The reaction of haloalkanoic acids or alkyl haloalkanoates with oxo group-contg. benzimidazoles, imidazoles, or pyrimidines gives the heat-stable diesters RO2C(CH2)nCHR1ZCHR1(CH2)nCO2R (I), where R = H, C1-4 alkyl, or Ph; R1 = H or C1-10 alkyl; n = 2-12; and Z = benzimidazole-1,3-diyl, imidazole-1,3-diyl or pyrimidine-1,3-diyl group-contg. 1-3 oxo groups. I are suitable for the prepn. of polyesters by melt polycondensation processes. Thus, reaction of 2-benzimidazolone [615-16-7] with Me g-chlorobutyrate [3153-37-5]at 96-101° in DMF-C6H6 contg. K2CO3 gave II [65328-12-3], which showed higher stability at 200° than the known N,N'-bis(2-carbethoxyethyl) analog. Ten other I were similarly prepd. Condensation of II, di-Me terephthalate, and 1,4-butanediol at 140-285° in the presence of (Me2CHO)4Ti gave a colorless polyester [65328-13-4] with relative viscosity 1. 65563-04-4 is just another one chemical used in this study.30. .

Identification of 2-benzimidazolinone as a metabolite of droperidol in man

Identification of 2-benzimidazolinone as a metabolite of droperidol in man. Van Boven, M. (Lab. Toxicol., Univ. Louvain, Louvain, Belg.). Toxicol. Lett., 2(1), 17-21 (English) 1978. CODEN: TOLED5. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) 2(3H)-benzimidazolinone (I) [615-16-7] was identified in human urine as a metabolite of the neuroleptic droperidol [548-73-2]. More than 5% of the administered droperidol dose was excreted as I.