CAS No.61869-08-7,Piperidine,3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)-, (3S,4R)- Suppliers

Detail of "61869-08-7"

CAS Number:

61869-08-7

Name:

Piperidine,3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)-, (3S,4R)-

Superlist Name:

Paroxetine

Molecular Structure:

Formula:

C₁₉H₂₀FNO₃

Molecular Weight:

329.37

Deleted CAS:

63952-24-9

Synonyms:

Piperidine,3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)-, (3S-trans)-;(-)-Paroxetine;(-)-trans-4-(4-Fluorophenyl)-3-(3,4-methylenedioxyphenoxymethyl)piperidine;Aropax;BRL 29060;Besitram;Casbol;FG 7051;Frosinor;Motivan;Paroxetine;PaxPar;Paxetil;Paxil;

Density:

1.213 g/cm³

Melting Point:

114-116 °C

Boiling Point:

451.674 °C at 760 mmHg

Flash Point:

226.964 °C

Appearance:

White solid

Transport Information:

UN 3249

Reference

p,p'-DDT-induced myoclonus in mice: the effect of enhanced 5-HT neurotransmission: p,p'-DDT-induced myoclonus in mice: the effect of enhanced 5-HT neurotransmission. Magnussen, Ib (Dep. Neurol., Aarhus Kommunehosp., Aarhus DK-8000, Den.). Acta Pharmacol. Toxicol., 56(2), 87-90 (English) 1985. CODEN: APTOA6. ISSN: 0001-6683. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) The acute behavioral consequence of intragastric DDT (I) [50-29-3] in high doses to mice is stimulus-sensitive myoclonus. The 5-HT precursor 5-hydroxytryptophan (5-HTP) [56-69-9] ameliorated (in contrast to natural precursor tryptophan) the myoclonus. The extracerebral decarboxylase inhibitor carbidopa [28860-95-9] and the selective 5-HT reuptake inhibitor paroxetine [61869-08-7] both enhanced the antimyoclonic action of 5-HTP. The effect was reversed by the 5-HT receptor blockers cinanserine [1166-34-3] and methylsergide [361-37-5]. The data add further evidence to a central serotonergic mechanism involved in DDT-induced myoclonus.

Size determination of binding polymers for [3H]imipramine and [3H]paroxetine in human platelet membranes: Size determination of binding polymers for [3H]imipramine and [3H]paroxetine in human platelet membranes. Mellerup, Erling T.; Plenge, Per; Nielsen, Mogens (Psychochem. Inst., Rigshosp., Copenhagen DK-2100, Den.). Eur. J. Pharmacol., 106(2), 411-13 (English) 1984. CODEN: EJPHAZ. ISSN: 0014-2999. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The specific high affinity binding of 3H-labeled imipramine [50-49-7] and 3H-labeled paroxetine [61869-08-7] to irradiated human platelet membranes was demonstrated. It was found that the mol. wt. for the polypeptide chain contg. the binding site for [3H]imimpramine was higher than the mol. wt. for the polypeptide chain binding [3H]paroxetine. Since imipramine and paroxetine both reportedly inhibit the transport of serotonin in serotonergic neurons and in human platelets and specific high affinity binding sites for [3H]imimpramine and [3H]paroxetine are located in these 2 cell types, it is suggested that the 2 binding sites may be located on 2 different subunits belonging to the serotonin transport system.

Detail of "61869-08-7"

Piperidine,3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)-, (3S,4R)-

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CAS No.61869-08-7 Paroxetine

CAS No.61869-08-7 Paroxetine

CAS No.61869-08-7 Paroxetine

CAS No.61869-08-7 Paroxetine

CAS No.61869-08-7 Paroxetine

CAS No.61869-08-7 Paroxetine

CAS No.61869-08-7 Paroxetine

CAS No.61869-08-7 Paroxetine

CAS No.61869-08-7 Paroxetine

CAS No.61869-08-7 Paroxetine

CAS No.61869-08-7 Paroxetine

CAS No.61869-08-7 Paroxetine

CAS No.61869-08-7 Paroxetine

CAS No.61869-08-7 Paroxetine

CAS No.61869-08-7 Paroxetine

CAS No.61869-08-7 Paroxetine

Reference