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CAS No.: | 6188-23-4 |
---|---|
Name: | 6-Bromoimidazo[1,2-a]pyridine |
Article Data: | 39 |
Molecular Structure: | |
Formula: | C7H5BrN2 |
Molecular Weight: | 197.034 |
Synonyms: | Imidazo[1,2-a]pyridine,6-bromo-; |
EINECS: | 689-291-9 |
Density: | 1.69 g/cm3 |
Melting Point: | 76-78 °C |
Boiling Point: | 165 °C(Press: 1.5 Torr) |
Solubility: | slightly soluble in water. |
Hazard Symbols: | Xn |
Risk Codes: | 22-36/37/38 |
Safety: | 22-26-36/37/39 |
PSA: | 17.30000 |
LogP: | 2.09680 |
Conditions | Yield |
---|---|
Stage #1: 2-chloroethanal; 5-bromo-2-pyridylamine In ethanol; water for 3h; Reflux; Stage #2: With sodium hydrogencarbonate In water | 100% |
In ethanol; water at 80℃; for 15h; | 100% |
In ethanol for 6h; Reflux; | 98% |
5-bromo-2-pyridylamine
Bromoacetaldehyde diethyl acetal
6-bromoimidazo[1,2-a]pyridine
Conditions | Yield |
---|---|
With hydrogen bromide In ethanol; water at 103℃; | 97% |
With hydrogen bromide In ethanol; water at 100℃; for 8h; | 87% |
With hydrogen bromide In ethanol; water at 100℃; for 8h; | 83% |
With hydrogenchloride; sodium hydrogencarbonate 1) H2O, a) r.t., b) 80 deg C, 2) r.t.; Yield given. Multistep reaction; |
Conditions | Yield |
---|---|
With hydrogen bromide In ethanol; water at 100℃; for 8h; | 87.2% |
5-bromo-2-pyridylamine
chloroacetaldehyde dimethyl acetal
6-bromoimidazo[1,2-a]pyridine
Conditions | Yield |
---|---|
Stage #1: 5-bromo-2-pyridylamine; chloroacetaldehyde dimethyl acetal With hydrogenchloride; sodium acetate In ethanol; water for 2.5h; Reflux; Stage #2: With sodium hydrogencarbonate In water pH=Ca. 7; | 64.28% |
With hydrogenchloride; sodium hydroxide; sodium acetate In water; water ethanol | |
With hydrogenchloride; sodium hydroxide; sodium acetate In water; water ethanol | |
With hydrogenchloride; sodium hydroxide; sodium acetate; sodium In water; water ethanol |
Conditions | Yield |
---|---|
In ethanol; water for 18h; Heating / reflux; |
5-bromo-2-pyridylamine
chloroacetaldehyde diethyl acetal
6-bromoimidazo[1,2-a]pyridine
Conditions | Yield |
---|---|
Stage #1: chloroacetaldehyde diethyl acetal With hydrogenchloride In water at 90℃; for 0.166667h; Stage #2: 5-bromo-2-pyridylamine With sodium acetate In ethanol; water for 0.333333h; Reflux; |
6-bromoimidazo[1,2-a]pyridine
methylamine
molybdenum hexacarbonyl
Conditions | Yield |
---|---|
With palladium [2'-(amino-κN)[1,1'-biphenyl]-2-yl-κC][[5-(diphenylphosphino)-9,9-dimethyl-9H-xanthen-4-yl]diphenylphosphine-κP](methanesulfonato-κO); 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine In tetrahydrofuran; 1,4-dioxane at 85℃; Inert atmosphere; Sealed tube; | 100% |
Conditions | Yield |
---|---|
With tris-(dibenzylideneacetone)dipalladium(0); triethylamine; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In toluene at 110℃; for 2h; Inert atmosphere; | 100% |
6-bromoimidazo[1,2-a]pyridine
6-bromo-3-nitro-imidazo[1,2-a]pyridine
Conditions | Yield |
---|---|
With sulfuric acid; nitric acid In water at 20℃; for 0.25h; | 99% |
With nitric acid In sulfuric acid | |
With nitric acid In sulfuric acid | |
With nitric acid In sulfuric acid |
6-bromoimidazo[1,2-a]pyridine
Conditions | Yield |
---|---|
With potassium phosphate; tris-(dibenzylideneacetone)dipalladium(0); dicyclohexyl(2',4',6'-triisopropyl-[1,1':3',1''-terphenyl]-2-yl)phosphane In 1,4-dioxane; water at 100℃; | 99% |
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IUPAC Name: 6-Bromoimidazo[1,2-a]pyridine
Following is the structure of 6-Bromoimidazo[1,2-a]pyridine (CAS NO.6188-23-4):
Empirical Formula: C7H5BrN2
Molecular Weight: 197.032
Index of Refraction: 1.688
Molar Refractivity: 44.26 cm3
Molar Volume: 116 cm3
Density: 1.69 g/cm3
Melting point: 76-78 °C
Polarizability: 17.54 10-24cm3
Surface Tension: 52.4 dyne/cm
Product Categories of 6-Bromoimidazo[1,2-a]pyridine (CAS NO.6188-23-4): blocks; Bromides; Imidazoles; Pyridines; CHIRAL CHEMICALS; Building Blocks; Imidazo[x,x-y]pyridine
Canonical SMILES: C1=CC2=NC=CN2C=C1Br
InChI: InChI=1S/C7H5BrN2/c8-6-1-2-7-9-3-4-10(7)5-6/h1-5H
InChIKey: FXPMFQUOGYGTAM-UHFFFAOYSA-N
6-Bromoimidazo[1,2-a]pyridine (CAS NO.6188-23-4) is used for chiral chemicals.
Hazard Codes: Xn
Risk Statements: 22-36/37/38
R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 22-26-36/37/39
S22:Do not breathe dust.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
Hazard Note: Harmful
HazardClass: IRRITANT
6-Bromoimidazo[1,2-a]pyridine , its cas register number 6188-23-4. It also can be called Imidazo[1,2-a]pyridine, 6-bromo- .