Reference

Dibenztroponeacetic and- propionic acids

Dibenztroponeacetic and- propionic acids. Potent new antiinflammatory agents. Dunn, James P.; Green, Dallas M.; Nelson, Peter H.; Rooks, Wendell H., II; Tomolonis, Albert; Untch, Karl G. (Inst. Org. Chem., Syntex Res., Palo Alto, Calif., USA). J. Med. Chem., 20(12), 1557-62 (English) 1977. CODEN: JMCMAR.Chemical with cas number 64584-35-6 also plays role. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Section cross-reference(s): 26 Of 19 title compds. and derivs. prepd. and tested in the rat paw edema antiinflammatory test and the mouse writhing analgesic assay, almost all had activity. The most active antiinflammatory, d-2-(5H-dibenzo[a,d]cyclohepten-5-on-2-yl)propionic acid (d-I) [58452-99-6], was prepd. by the Wittig reaction of 2-(carboxymethyl)benzyltriphenylphosphonium bromide [60494-73-7] with m-tolualdehyde [620-23-5] followed by hydrogenation, cyclization, bromination and debromination to give 2-methyl-5H-dibenzo[a,d]cyclohepten-5-one [61565-78-4]; Me group bromination, ketalization, cyanation, hydrolysis, and side chain methylation gave dl-I [58452-80-5], which was resolved using l-amphetamine to give d-I. With a potency .apprx.70 times that of phenylbutazone in the rat paw assay and 2-3 times that of indomethacin in long-term animal assays d-I is one of the more potent antiinflammatory agents so far reported. Several compds. showed analgesic activity in the mouse writhing assay, with d-I being most active. Structure-activity relations are discussed. .

Gas chromatography of benzaldehyde, o-, m- and p-tolualdehydes using glass capillary columns

Gas chromatography of benzaldehyde, o-, m- and p-tolualdehydes using glass capillary columns. Hoshika, Yasuyuki; Takata, Yoshinori (Aichi Environ. Res. Cent., Nagoya, Japan). Bunseki Kagaku, 25(8), 529-33 (Japanese) 1976. CODEN: BNSKAK. DOCUMENT TYPE: Journal CA Section: 59 (Air Pollution and Industrial Hygiene) Section cross-reference(s): 80 Aldehydes, e.g. benzaldehyde [100-52-7] and tolualdehydes were detected in exhaust gases by gas chromatog. Because of the dfficulty of direct sepn. of m- [620-23-5] and p-tolualdehyde [104-87-0], an indirect method was adopted by formation of a Schiff base with an aliph. primary amine, e.g. BuNH2. Gas chromatog. conditions were: glass column (0.25 mm i.d. x 30 m length) coated with polyethylene glycol 20M; 100.degree.; N 1.3 ml/min; n-Heptadecane internal std. Relative retentions of RC6H4-CH:N(CH2)3Me were: R = H 0.97; R = o-Me 1.48; R = m-Me 1.55; R = p-Me 1.58; and R = C17H36 1.00. The min. detectable aldehydes were 0.01 .mu.g. By using a condensing trap, 0.3 ppb of aldehyde could be detected by condensing 30 L of exhaust gas.