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621-64-7

Basic Information
CAS No.: 621-64-7
Name: N-NITROSODI-N-PROPYLAMINE
Article Data: 20
Molecular Structure:
Molecular Structure of 621-64-7 (N-NITROSODI-N-PROPYLAMINE)
Formula: C6H14 N2 O
Molecular Weight: 130.19
Synonyms: Dipropylamine,N-nitroso- (6CI,7CI,8CI); Dipropylnitrosamine; N,N-Dipropylnitrosamine;N-Nitroso-N-di-n-propylamine; N-Nitrosodi-n-propylamine;N-Nitrosodipropylamine; NSC 133
Density: 0.92
Boiling Point: 113 °C / 40mmHg
Flash Point: 10 °C
Solubility: 9,900 mg/L at 25 °C (Mirvish et al., 1976)
Hazard Symbols: T,N,F
Risk Codes: R45; R22; R51/53; R39/23/24/25; R23/24/25; R11
Safety: Confirmed carcinogen with experimental carcinogenic, neoplastigenic, tumorigenic data. Moderately toxic by ingestion and subcutaneous routes. An experimental teratogen. Human mutation data reported. When heated to decomposition it emits toxic fumes of NOx. See also NITROSAMINES.

Analytical Methods:

   

For occupational chemical analysis use OSHA: #27 or NIOSH: Nitrosamines 2522.

PSA: 32.67000
LogP: 1.78980
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Chemistry

Empirical Formula: C6H14N2O
Molecular Weight: 130.1882 g/mol
EINECS: 210-698-0
Index of Refraction: 1.451
Density: 0.93 g/cm3
Flash Point: 82.6 °C
Enthalpy of Vaporization: 42.42 kJ/mol
Boiling Point: 206 °C at 760 mmHg
Vapour Pressure: 0.348 mmHg at 25 °C
Storage tempreture: 2-8 °C
Appearance: Clear to pale yellow liquid
Structure of N-Nitrosodi-n-propylamine (CAS NO.621-64-7):
              
IUPAC Name: N,N-Dipropylnitrous amide
Product Categories: Nitrosamine;Alpha Sort;Amines;Chemical Class;N-OAlphabetic 

Toxicity Data With Reference

1.    

mma-sat 1 µmol/plate

    GANNA2    Gann. Japanese Journal of Cancer Research. 75 (1984),8.
2.    

dns-hmn:hla 100 µmol/L

    CNREA8    Cancer Research. 38 (1978),2621.
3.    

scu-ham TDLo:100 mg/kg (14D preg):NEO,TER

    ZKKOBW    Zeitschrift fuer Krebsforschung und Klinische Onkologie. 90 (1977),79.
4.    

orl-rat LD50:480 mg/kg

    ZEKBAI    Zeitschrift fuer Krebsforschung. 69 (1967),103.
5.    

scu-rat LD50:487 mg/kg

    JNCIAM    Journal of the National Cancer Institute. 54 (1975),937.
6.    

scu-mus LD50:689 mg/kg

    ZKKOBW    Zeitschrift fuer Krebsforschung und Klinische Onkologie. 90 (1977),253.
7.    

scu-ham LD50:600 mg/kg

    JNCIAM    Journal of the National Cancer Institute. 51 (1973),1019.

Consensus Reports

NTP 10th Report on Carcinogens. IARC Cancer Review: Group 2B IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 ,1987,p. 56.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Sufficient Evidence IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 17 ,1978,p. 177.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Human Limited Evidence IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 17 ,1978,p. 177.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . EPA Genetic Toxicology Program. Community Right-To-Know List. Reported in EPA TSCA Inventory.

Safety Profile

Confirmed carcinogen with experimental carcinogenic, neoplastigenic, tumorigenic data. Moderately toxic by ingestion and subcutaneous routes. An experimental teratogen. Human mutation data reported. When heated to decomposition it emits toxic fumes of NOx. See also NITROSAMINES.
Hazard Codes: ToxicT,DangerousN,FlammableF
Risk Statements: 45-22-51/53-39/23/24/25-23/24/25-11 
R11:Highly flammable. 
R22:Harmful if swallowed. 
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed. 
R39:Danger of very serious irreversible effects. 
R45:May cause cancer. 
R51/53:Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
Safety Statements: 53-45-61-36/37 
S36/37:Wear suitable protective clothing and gloves. 
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) 
S53:Avoid exposure - obtain special instructions before use. 
S61:Avoid release to the environment. Refer to special instructions / safety data sheets.

Standards and Recommendations

DFG MAK: Animal Carcinogen, Suspected Human Carcinogen

Analytical Methods

For occupational chemical analysis use OSHA: #27 or NIOSH: Nitrosamines 2522.

Specification

 N-Nitrosodi-n-propylamine ,its cas register number is 621-64-7. It also can be called N-Nitroso-N-propyl-1-propanamine ; Oryzalin metabolite ; N-Nitroso-N-propylpropan-1-amin ;and 1-Propanamine, N-nitroso-N-propyl- . N-Nitrosodi-n-propylamine (CAS NO.621-64-7) is a nitrated amine derivative, and some may burn but none ignite readily.