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CAS No.: | 62937-45-5 |
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Name: | D-Prolinamide |
Article Data: | 4 |
Molecular Structure: | |
Formula: | C5H | 10N2O
Molecular Weight: | 114.147 |
Synonyms: | 2-Pyrrolidinecarboxamide,(R)-;(2R)-2-Carbamoylpyrrolidine;(R)-Prolinamide;(R)-Pyrrolidine-2-carboxamide; |
EINECS: | 613-116-7 |
Density: | 1.106 g/cm3 |
Melting Point: | 95-97 °C |
Boiling Point: | 303.6 °C at 760 mmHg |
Flash Point: | 137.4 °C |
Solubility: | Soluble in water. |
Appearance: | Crystalline |
Hazard Symbols: | C,T |
Risk Codes: | R34 |
Safety: | 24/25 |
PSA: | 55.12000 |
LogP: | 0.25280 |
(2R)-2-carbamoyl-pyrrolidine-1-carboxylic acid benzyl ester
(R)-prolinamide
Conditions | Yield |
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With 10% palladium on carbon; hydrogen In methanol for 7h; | 100% |
With hydrogen; palladium on activated charcoal In methanol for 9h; Ambient temperature; | 87.3% |
(R)-prolinamide
Conditions | Yield |
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With ammonia In ethanol at 0 - 20℃; Large scale; | 80% |
Z-D-proline
(R)-prolinamide
Conditions | Yield |
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Multi-step reaction with 2 steps 1: 1.) triethylamine, isobutyl chloroformate, 2.) ammonia / 1.) chloroform, 0 deg C, 2 h, 2.) chloroform, RT, overnight 2: 87.3 percent / hydrogen / 10percent palladium on carbon / methanol / 9 h / Ambient temperature View Scheme |
D-Prolin
(R)-prolinamide
Conditions | Yield |
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Multi-step reaction with 3 steps 1: sodium hydroxide / H2O / Ambient temperature 2: 1.) triethylamine, isobutyl chloroformate, 2.) ammonia / 1.) chloroform, 0 deg C, 2 h, 2.) chloroform, RT, overnight 3: 87.3 percent / hydrogen / 10percent palladium on carbon / methanol / 9 h / Ambient temperature View Scheme |
(R)-2-carbamoylpyrrolidine-1-carboxylic acid tert-butyl ester
(R)-prolinamide
Conditions | Yield |
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Stage #1: (R)-2-carbamoylpyrrolidine-1-carboxylic acid tert-butyl ester With trifluoroacetic acid at 25℃; Stage #2: With N-ethyl-N,N-diisopropylamine In dichloromethane at 25℃; |
(R)-prolinamide
Conditions | Yield |
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With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 18h; | 92.9% |
(R)-prolinamide
Conditions | Yield |
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In N,N-dimethyl-formamide at 80℃; | 92% |
9-bromo-10-(bromomethyl)-2,3,6,7-tetramethoxyphenanthrene
(R)-prolinamide
(R)-1-[(9-bromo-2,3,6,7-tetramethoxyphenanthren-10-yl)methyl]pyrrolidine-2-carboxamide
Conditions | Yield |
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With potassium carbonate In N,N-dimethyl-formamide for 8h; Reflux; | 91% |
(R)-prolinamide
Conditions | Yield |
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Stage #1: 2-chloro-N-(1-(3,4,5-trimethoxyphenyl)-1H-imidazol-4-yl)thieno[3,2-d]pyrimidin-4-amine; (R)-prolinamide With N-ethyl-N,N-diisopropylamine In 1-methyl-pyrrolidin-2-one at 130℃; for 18h; Microwave irradiation; Stage #2: With hydrogenchloride In water; acetonitrile | 90% |
(R)-prolinamide
Conditions | Yield |
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Stage #1: 2-((4-(4,6-bismorpholine-1,3,5-triazin-2-yl)phenyl)amino)-1H-benzo[d]imidazole-6-carboxylic acid With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 0.666667h; Inert atmosphere; Stage #2: (R)-prolinamide In N,N-dimethyl-formamide at 80℃; for 8h; Inert atmosphere; | 88% |
Molecular Structure of H-D-Pro-NH2 (CAS NO.62937-45-5):
Molecular Formula: C5H 10N2O
Molecular Weight: 114.15
IUPAC Name: Dichloropalladium
CAS NO: 62937-45-5
Melting Point: 95-97°C
Index of Refraction: 1.491
Molar Refractivity: 29.9 cm3
Molar Volume: 103.1 cm3
Surface Tension: 41.4 dyne/cm
Density: 1.106 g/cm3
Flash Point: 137.4 °C
Enthalpy of Vaporization: 54.39 kJ/mol
Boiling Point: 303.6 °C at 760 mmHg
Vapour Pressure of H-D-Pro-NH2 (CAS NO.62937-45-5): 0.000923 mmHg at 25°C
Classification Code: Amide ; Aminoacids derivatives ; Pyrrolidines ; Proline [Pro, P] ; Amino Acids and Derivatives
InChI: InChI=1/C5H10N2O/c6-5(8)4-2-1-3-7-4/h4,7H,1-3H2,(H2,6,8)/t4-/m1/s1
InChIKey: VLJNHYLEOZPXFW-SCSAIBSYBV
Std. InChI: InChI=1S/C5H10N2O/c6-5(8)4-2-1-3-7-4/h4,7H,1-3H2,(H2,6,8)/t4-/m1/s1
Std. InChIKey: VLJNHYLEOZPXFW-SCSAIBSYSA-N
H-D-Pro-NH2 (CAS No.62937-45-5), it also can be called 2-Pyrrolidinecarboxamide, (2R)- ; D-Prolinamide ; (R)-Pyrrolidine-2-carboxylic acid amide ; (R)-Prolinamide .