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643-20-9

Basic Information
CAS No.: 643-20-9
Name: Hexahydro-1H-pyrrolizine
Article Data: 38
Molecular Structure:
Molecular Structure of 643-20-9 (Hexahydro-1H-pyrrolizine)
Formula: C7H13 N
Molecular Weight: 111.187
Synonyms: 1-Azabicyclo[3.3.0]octane;Hexahydropyrrolizine; NSC 145060; NSC 90874; Pyrrolizidine
Density: 0.97g/cm3
Boiling Point: 145.8°C at 760 mmHg
Flash Point: 34.2°C
PSA: 3.24000
LogP: 1.18250
Synthetic route
80662-83-5

1-Benzyloxycarbonyl-5-oxoperhydroazocine

643-20-9

pyrrolizidine

Conditions
ConditionsYield
With perchloric acid; hydrogen; palladium on activated charcoal In methanol under 760.2 Torr; for 6h; Ambient temperature;95%
32548-24-6

1,2,5,6,7,8-hexahydro-3H-pyrrolizin-3-one

643-20-9

pyrrolizidine

Conditions
ConditionsYield
With dimethylsulfide borane complex In tetrahydrofuran at 20℃; for 16h;77%
With lithium aluminium tetrahydride In tetrahydrofuran; diethyl ether Cooling with ice; Reflux;
209409-40-5

2-(3-Oxo-propyl)-pyrrolidine-1-carboxylic acid benzyl ester

643-20-9

pyrrolizidine

Conditions
ConditionsYield
With ammonium formate; palladium on activated charcoal In methanol for 0.5h; Heating;55%
1121-92-2

heptamethyleneimine

643-20-9

pyrrolizidine

Conditions
ConditionsYield
With lithium bromide In water; acetonitrile for 2.5h; bicyclization by electrochemical oxidation; other cyclic amines;52%
With lithium bromide In water; acetonitrile for 2.5h; electrochemical oxidation, C anode, 100 mA;52%
18356-28-0

tetrahydro-pyrrolizin-3,5-dione

643-20-9

pyrrolizidine

Conditions
ConditionsYield
With lithium aluminium tetrahydride; diethyl ether
3981-10-0

1,4,7-tribromo-heptane

643-20-9

pyrrolizidine

Conditions
ConditionsYield
With methanol; ammonia at 140℃;
34999-74-1

4-hydroxyimino-heptanedioic acid diethyl ester

643-20-9

pyrrolizidine

Conditions
ConditionsYield
With 1,4-dioxane; copper oxide-chromium oxide at 265℃; under 257428 Torr; Hydrogenation;
7766-83-8

dimethyl 4-nitro-1,7-heptanedioate

643-20-9

pyrrolizidine

Conditions
ConditionsYield
With methanol; platinum Hydrogenation.Hydrierung des Reaktionsprodukts an Kupferoxid-Chromoxid bei 250grad/340-400at;
100371-16-2

pyrrol-2-ylmethyl-malonic acid diethyl ester

643-20-9

pyrrolizidine

Conditions
ConditionsYield
With 1,4-dioxane; copper oxide-chromium oxide at 260℃; under 176522 Torr; Hydrogenation;
6940-76-7

1-iodo-3-chloro-propane

85152-51-8

pyrrolidine tert-butylformamidine

643-20-9

pyrrolizidine

Conditions
ConditionsYield
Yield given. Multistep reaction;
Downstream Products
14129-07-8
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