Detail of "64840-90-0"

Reference

Antagonistic property of eperisone in muscarinic cholinergic receptor binding assays

Antagonistic property of eperisone in muscarinic cholinergic receptor binding assays. Ogawa, Norio; Nukina, Itaru; Takayama, Haruhiko; Ota, Zensuke (Med. Sch., Okayama Univ., Okayama 700, Japan). Neurosciences (Kobe, Jpn.), 11(1), 33-6 (English) 1985. CODEN: NUOCDO. ISSN: 0388-7448. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Eperisone (I) [64840-90-0], an anti-spastic agent, displaced the receptor binding of [3H]quinuclidinylbenzilate (QNB) in a dose-related manner; its displacement curve did not shift to the right in the presence ofGTP [86-01-1], similarly to those of atropine and trihexyphenidyl, which are antagonists of muscarinic acetylcholine receptors (mACh-R). On the other hand, the displacement curve of pilocarpine, a mACh-R agonist, against [3H]QNB receptor binding showed a shift to the right by addn. of GTP. Thus, eperisone is an antagonist of mACh-R, and since an earlier study showed it to markedly improve tremor in patients with Parkinson's disease, eperisone may be used effectively in the treatment of the disease.