64840-90-0 Usage
Description
Apiresone is a central skeletal muscle relaxant with various pharmacological effects. Animal experiments suggest that eperisone hydrochloride can dose-dependently inhibit decerebral tonic (γ-rigid) and ischemic decerebral tonic (α-rigid) induced by interthalamic transection in rats, and inhibit the stimulation of the dorsal spinal cord in cats with spinal cord injury. The evoked monosynaptic and polysynaptic reflex potentials may reduce the sensitivity of muscle spindles by inhibiting the γ-neuron system.
Pharmacological action
Eperisone is an antispasmodic agent used in the study of disorders characterized by muscle stiffness and pain. It works by relaxing skeletal and vascular smooth muscles, such as reducing muscle tone, improving circulation and suppressing pain reflexes. Eperisone is a centrally acting muscle relaxant that inhibits pain reflex pathways and has vasodilatory effects.
Side effects
Serious adverse reactions include: shock, abnormal liver function, abnormal renal function, abnormal blood picture; the following adverse reactions may occur: skin, rash, itching, etc.; mental nerves, insomnia, headache, drowsiness, body stiffness, numbness of limbs, decreased consciousness, limbs Weakness, unsteady standing, etc.; Digestive system, nausea, vomiting, loss of appetite, stomach discomfort, abnormal liver function, etc.; Urinary system, urinary retention, urinary incontinence, feeling of incomplete urination, etc., occasionally abnormal renal function; systemic symptoms, Fatigue, occasional dizziness, decreased muscle tension, etc.; other, facial flushing, sweating, etc.
Originator
Myonal,Eisai,Japan,1983
Therapeutic Function
Muscle relaxant
Check Digit Verification of cas no
The CAS Registry Mumber 64840-90-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,4,8,4 and 0 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 64840-90:
(7*6)+(6*4)+(5*8)+(4*4)+(3*0)+(2*9)+(1*0)=140
140 % 10 = 0
So 64840-90-0 is a valid CAS Registry Number.
InChI:InChI=1/C17H25NO/c1-3-15-7-9-16(10-8-15)17(19)14(2)13-18-11-5-4-6-12-18/h7-10,14H,3-6,11-13H2,1-2H3
64840-90-0Relevant articles and documents
TOLPERISONE ANALOGS AND METHODS OF USE
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Page/Page column 38, (2019/10/29)
The present invention is, in part, directed to tolperisone analogs (e.g., compounds of formula (I), (I-a), (I-b), (II), (Il-a), (III), (Ill-a), (ΙΙΙ-b), (III-c), (IV), (IV-a), (V), or (V-a)) and methods of use thereof for the treatment of various conditions including elevated muscle tone and tension (e.g., spasticity, muscle spasm). In one aspect, the tolperisone analogs disclosed herein have an additional substituent at the α-position, which blocks the generation of a β- elimination product.
Propiophenone derivatives in the treatment of pathological muscular conditions
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, (2008/06/13)
New propiophenone derivatives prepared by the reaction of propiophenone, formaldehyde and piperidine, as well as pharmacologically acceptable acid-addition salts thereof are provided, which possess improved pharmacological activities such as anti-tremorine and anti-nicotine activities superior to those of the known analogous compound. The new compounds are useful for the therapeutic treatment of human patient suffering from pathological muscular contracture, spastic paralysis due to cerebral apoplexy, spinal and cerebral palsies and the like.
