Detail of "65-61-2"

Reference

A comparative analysis of the effects of Acridine Orange, Hycanthone, Lucanthone and Promethazine on the embryonic development of sea-urchin eggs, Lytechinus variegatus, Lamarck, var

A comparative analysis of the effects of Acridine Orange, Hycanthone, Lucanthone and Promethazine on the embryonic development of sea-urchin eggs, Lytechinus variegatus, Lamarck, var. Atlanticus. Tse, Hero Gondinho; Gomes, Messias Carlos Galvao; Tse, Maria do Carmo; Cesario, Maria Dalva; Medina, Heitor; Medina, Thais (Inst. Basico Biol. 60-87-7 and 479-50-5 are also occured in this study. Med. Agric., UNESP, Botucatu 18 600, Brazil). Rev. Cienc. Biomed., 3 33-8 (English) 1982. CODEN: RCBIDV. ISSN: 0101-322X. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) The effects of anthracene-like compds., Acridine Orange [65-61-2], Hycanthone [3105-97-3], Lucanthone [479-50-5] and Promethazine [60-87-7] on the embryonic development of sea-urchin eggs, were studied comparatively on the statistical basis. Promethazine was the strongest in producing morphol. changes, followed by Lucanthone. Acridine Orange and Hycanthone seemed to be similar in their mode of action and were less toxic. .

Induction of cytoplasmically inherited respiration-deficient ('petite') mutants by photodynamic action of acridine compounds

Induction of cytoplasmically inherited respiration-deficient ('petite') mutants by photodynamic action of acridine compounds. Iwamoto, Y.; Mifuchi, I.; Yielding, L. W.; Firth, W. J., III; Yielding, K. L. (Dep. Microbiol., Shizuoka Coll. Pharm., Shizuoka, Japan). Mutat. Res., 125(2), 213-19 (English) 1984. CODEN: MUREAV. ISSN: 0027-5107. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) All acridines used acriflavine [65589-70-0], proflavine [92-62-6], acridine orange [65-61-2], and 3-azido-10-methylacridinium chloride (I) [78276-15-0] produced killing in yeast (Saccharomyces cerevisiae) cells when activated with visible light. Acriflavine, proflavine, and I, but not acridine orange, produced petite and sectored colonies. Both cell killing and petite induction by light activation of acriflavine resulted apparently from photodynamic action mediated by singlet O since the effect were prevented by either NaN3 or anaerobiosis. The biol. 7782-44-7 and 260-94-6 which are cas registry numbers of chemicals are mentioned. effects of I were due to a photodynamic action analogous to that of acriflavine. NaN3 or anaerobiosis prevented the light-activated effects of I despite the initial chem. breakdown of the azido deriv. induced by light was not affected. Cells suspended in D2O demonstrated an enhanced response to I with irradn. Thus, singlet O mediates the light-activated biol. effects of both acriflavine and I. .